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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Acyclovir release from the plasticized branched polyesters
 Černohousová, Lenka ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
This diploma thesis aims to study the liberation profile of the acyclovir from plasticized branched polyesters. Polyesters of D,L-lactic acid and glycolic acid, branched using pentaerythritol, dipentaerythritol or tripentaerythritol in different concentrations, plasticized by 30% trietylcitrate were examined. The theoretical part summarizes the liberation of drugs from different modified drug systems and properties of natural and synthetic degradable polymers. Modified static dissolution test was done at 37řC using phosphate citrate buffer. The acyclovir was released within 24 hours at the tested carriers branched by dipentaerythritol with low molecular weight. Therefore it is suitable for short-term liberation. Carriers branched by pentaerythritol or tripentaerythritol with higher molecular weight proved to be optimal for extended release. Keywords: drug release, acyclovir, branched oligoesters, plasticizers
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