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Genetic analysis of susceptibility of mice to Leishmania major infection
Čepičková, Marie ; Černý, Jan (referee)
The protozoa of the genus Leishmania cause a complex of diseases called leishmaniases. The disease can be asymptomatic or manifest with a wide range of symptoms, including severe systemic disease that can be fatal. Susceptibility of the host to infection is controlled by many genes, but the mechanism of regulation remains unknown. Host sex also influences the course of infection. The disadvantages of genetic analyses performed in humans can be overcome by using a mouse model. To study the genes that influence susceptibility to Leishmania major infection in mice, a special model consisting of 20 recombinant CcS/Dem congenic strains was developed. These strains were generated by crossing BALB/cHeA (susceptible to infection) and STS/A (resistant to infection) strains. Each strain in the CcS/Dem series represents a unique combination of 12.5 % of the genome of the STS/A strain and 87.5% of the genome of the BALB/cHeA strain. F2 hybrids between the BALB/c and CcS-9 strains were used in the present work. The mice were infected with L. major and after eight weeks the infection parameters were evaluated: size of skin lesions, hepatomegaly, splenomegaly, amount of parasites in the spleen and lymph nodes, degree of eosinophil infiltration in the lymph nodes, and serum levels of IFNγ, IL-4, IL-10, IL-12,...
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The control of the finances of municipalities
Čepičková, Marie ; Sedmihradská, Lucie (advisor) ; Špinerová, Zuzana (referee)
This thesis deals with control of the finances of municipalities in the Czech republic. In the first part there is based on literature and law review and described the topic. The second and third part of thesis contain the analysis of specific parts of financial control and review of management of municipalities with emphasis on analysis of final findings given by the Ministry of finance of the Czech republic. In the last part of thesis there are closely compared and evaluated information about control of the finances of selected municipalities in Tábor's district. It turned out that control of the finances of municipalities is stable part of municipality's life and it is at a good level overall. The review of management of municipalities is at a higher level than the financial control. The control of municipalities is effective and it does not matter, if it is checked by controller of the Regional autority or by external auditor.
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The real estate tax in chosen municipalities
Čepičková, Marie ; Sedmihradská, Lucie (advisor) ; Sedmihradská, Lucie (referee)
This thesis deals with impacts of amendments to the law of real estate tax with emphasis on changes in revenues of eight towns in former Tábor's district, which are connected with implementation of so called local coefficient. In the first part there is based on literature review described the topic and in detail characterized the recent legislative changes. The second part of thesis contains the analysis of tax and total revenues and the revenues from the real estate tax. Obtained data from database ARIS there are compared with information from public notices and questionnaires, which officials of towns filled up. In the last part of thesis there are closely analyzed revenues of real estate tax in towns Soběslav and Sezimovo Ústí and there are indicated possibly impacts of implementation of local coefficient. It turned out that all towns newly took advantage of some possibilities for increasing revenues of real estate tax. In Soběslav, Veselí nad Lužnicí and Mladá Vožice there were changes of basic correction coefficient according to number of the population. Towns Tábor, Soběslav, Sezimovo Ústí, Bechyně and Chýnov used the possibility to implement local coefficient in the amount of two, whereas all of towns plan for situation reevaluation.
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