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Biological properties of titanium alloy coated with hydroxyapatite in relation to immediate implant loading
Seydlová, Michaela ; Dostálová, Taťjána (advisor) ; Racek, Jaroslav (referee) ; Jelínková, Helena (referee)
Coating dental implants with hydroxyapatite may give certain advantages such as active encouragement to new bone growth, a lower rejection rate and an improved long-term prosthesis fixation. The biological properties of dental implants coated by the sandwich technique with a thin layer of hydroxyapatite and an interlayer of zirconia were evaluated. The implant samples were covered by pulsed laser deposition. The aim of this study is to evaluate the cytotoxicity and the surface characteristics of the titanium targets modified with zirconia and hydroxyapatite. We used a direct test of cytotoxicity, tests of fibroblasts adhesion and proliferation using counting of harvested cells and providing a MTT assay. No changes in the morphology or the proliferation rate of the cells used were found in the presence of the modified titanium targets. The results show adhesion and cell proliferation, which in turn implies that the studied material is not cytotoxic and is suitable for cell colonization. Titanium modified with zirconia and crystalline hydroxyapatite can improve the biological properties and so can be benefitially employed in oral bone surgery. Powered by TCPDF (www.tcpdf.org)
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Biological and mechanical properties of titanium implant covered with hydroxyapatite and zirconia layers and the approach to the immediate loading of dental implants
Teuberová, Zuzana ; Dostálová, Taťjána (advisor) ; Racek, Jaroslav (referee) ; Jelínková, Helena (referee)
Dental implantology is a branch, which has started a rapid evolution over the last years. All of the experts dealing with implantation are focused on extending indications for the application of the used materials to reduce the time period of therapy. Coating of the implants is a possible way how to treat patients in a shorter time period with the similar results as following the classical Bránemark protocol.Hydroxyapatite is one of the most attractive materials for human hard tissue implants because of its close resemblance to the bone and the teeth. Its positive influence on the healing process called osseointegration is obvious. Hydroxyapatite is of a brittle nature and limits the applications as the main solid material for the dental implants. Zirconia ceramics have several advantages such as the high strength and it is frequently used to reinforce other ceramics. The concept of adding zirconia as the second phase to hydroxyapatite significantly increased the bonding strenght.In the dissertation pulsed laser deposition is shown as one of the coating method. The bioceramic zirconia samples were characterized by methods for thin solid film analysis such as X-ray diffraction, morfology investigation by electrone microscope and measurement of the film thickness. Afterwards we examined the mechanical...
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