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National Repository of Grey Literature 32 records found  beginprevious31 - 32  jump to record: Search took 0.00 seconds. 
Predictor of the Effect of Amino Acid Substitutions on Protein Function
 Musil, Miloš ; Martínek, Tomáš (referee) ; Bendl, Jaroslav (advisor)
This thesis discusses the issue of predicting of the effect of amino acid substitutions on protein funkcion, based on phylogenetic analysis method, inspired by tool MAPP. Significant number of genetic diseases is caused by nonsynonymous SNPs manifested as single point mutations on the protein level. The ability to identify deleterious substitutions could be useful for protein engineering to test whether the proposed mutations do not damage protein function same as for targeting disease causing harmful mutations. However the experimental validation is costly and the need of predictive computation methods has risen. This thesis describes desing and implementation of a new in silico predictor based on the principles of evolutionary analysis and dissimilarity between original and substituting amino acid physico-chemical properties. Developed algorithm was tested on four datasets with 74,192 mutations from 16,256 sequences in total. The predictor yields up to 72 % accuracy and in the comparison with the most existing tools, it is substantially less time consuming. In order to achieve the highest possible efficiency, the optimization process was focused on selection of the most suitable (a) third-party software for calculation of a multiple sequence alignment, (b) overall decision threshold and (c) a set of physico-chemical properties.
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The Development of Tourism in the Velkobřezensko microregion focused on Velké Březno
 Hrebíková, Kateřina ; Syrovátka, Oldřich (advisor) ; Musil, Miloš (referee)
This thesis deals with tourism development and sustainability. Together with theoretical examination, a case study of the Velke Brezno castle will be presented, including communication activities and new opportunities for future use of the castle. The aim of this study is to find gaps in the so-far-applied communication activities and the use of the castle and to suggest solutions which would correspond with the local government's vision for community development and the demand of visitors. Furthermore, the solution should support tourism development in the region of Velke Brezno.
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National Repository of Grey Literature : 32 records found   beginprevious31 - 32  jump to record:
See also: similar author names
13 MUSIL, Marek
27 MUSIL, Martin
13 Musil, Marek
2 Musil, Marian
27 Musil, Martin
1 Musil, Michael
8 Musil, Michal
11 Musil, Milan
1 Musil, Miloslav
4 Musil, Miroslav
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