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Azaphthalocyanines as new structural group of fluorescence quencher.
Kopecký, Kamil ; Doležal, Martin (advisor) ; Lang, Kamil (referee) ; Pour, Milan (referee)
1 SUMMARY This dissertation thesis deals with searching of structurally new non-fluorescent quenchers of fluorescence, which may be used for preparation of molecular probes. These potential quenchers are derived from asymmetrically substituted alkylaminoderivatives of tetrapyrazinoporphyrazines - azaphthalocyanines. As the part of this work is preparation of precursors - 5,6-disubstituted pyrazine-2,3-dicarbonitriles. They are starting material for the preparation of final substances - tetrapyrazinoporphyrazines bearing different functional moieties. In total were prepared: 14 intermediates (3 of them have been described in our department) 13 final tetrapyrazinoporphyrazines (1 of them has been described in our department) 1 modified solid phase suitable for synthesis of marked oligonucleotides 2 by-products 23 undescribed compounds were prepared. Synthesis of 4 substances was not successful. Final products were tested for their singlet oxygen quantum yields, stability in solutions used for synthesis of oligonucleotides and subsequently ability of quenching of commercially available fluorofor Cy5® . This ability was compared with commercially available quencher Black Hole Quencher-2® . As a part of this work is confirmation of distribution of congeners arising during the statistical tetramerization of...
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16th International Symposium on Intercalation Compound - ISIC16. Abstracts Book
Zima, Vítězslav ; Kavan, Ladislav ; Čejka, Jiří ; Lang, Kamil ; Vlček, Milan ; Beneš, L. ; Svoboda, Jan ; Melánová, Klára ; Frumarová, Božena ; Knotek, P. ; Jůza, Josef ; Látalová, Petra
The topic of the papers published in this proceedings is chemistry, properties and applications of intercalation compounds and related materials.
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Nanotextilie produkující singletní kyslík
Mosinger, J. ; Jirsák, O. ; Kubát, Pavel ; Lang, Kamil ; Mosinger, B.
Medicine is facing many challenges today. One of them is that more and more bacterial strains are becoming resistant to antibiotics. In addition, antibiotics and antiseptics are potentially polluting our environment and are, or should be, restricted from common use. We developed a material with bactericidal properties that are activated by light and are confined to the narrow space defined by its surface and shape. This material is nanopolluting and its active substance is non-toxic and biodegradable.
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Neobvyklá stechiometrie kalixaren-močovinových derivátů
Dudič, M. ; Lang, Kamil
Calix[4]arenes bearing two p-nitrophenyl-ureido functions at the upper rim are effective anion binders. The stoichiometry of complexation depends on the substitution pattern (distal vs proximal) and anion concentration. While the distally substituted receptor forms 1:1 complexes with anions, the corresponding proximal derivative prefers the 2:1 stoichiometry (calixarene: anion) under identical conditions.
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