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A study of compressiblity and properties of tablets from coprocessed dry binder with manntol and croscarmellose sodium for orodispersible tablets.
Kamarýtová, Martina ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Martina Kamarýtová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of compressibility and properties of tablets from coprocessed dry binder with mannitol and croscarmellose sodium for orodispersible tablets. This thesis deals with the study of directly compressible tableting materials and tablets with Parteck® ODT, which is designed for orodispersible tablets. The effect of three lubricants on the properties of tableting materials and tablets is evaluated. Tested lubricants are magnesium stearate, calcium stearate and sodium stearyl fumarate in concentrations of 0,5 and 1 %. Flow properties, compressibility, ejection force, tensile strength and disintegration time of tablets are tested. The compressibility is evaluated by the energy profile of compression process. Lubricants did not improve the flowability of Parteck® ODT. The total energy of compression increased with compression force and highest values were at the tableting material with 0,5 % magnesium stearate. The values of plasticity decreased with compression force, highest values were at the tableting material with 0,5 % sodium stearyl fumarate. The ejection force increased with compression force, the...
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A study of directly compressible tableting materials and matrix tablets with polyvinyl alcohol.
Vildová, Lucie ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Lucie Vildová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis A study of directly compressible tableting materials and matrix tablets with polyvinyl alcohol This work evaluates and compares the properties of directly compressible tableting materials and matrix tablets containing the combination of α-lactose monohydrate and microcrystalline cellulose in the ratio of 3:1 in a physical mixture and in a coprocessed dry binder. Polyvinyl alcohol is used as the retarding agent at the concentrations of 30, 40 and 50 %. Tested parameters are compressibility, tensile strength of tablets and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Dissolution testing is performed using rotating basket method. The values of total energy of compression, plasticity and tensile strength of the tablets were higher in the tableting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. The dissolution behavior of tablets, which contained physical mixture or coprocessed dry...
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Study of bulk and consolidation properties of size fractions of anhydrous lactose
Dostálová, Eliška ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Supervisor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Ing. Hana Hurychová Student: Eliška Dostálová Title of Thesis: Study of bulk and consolidation properties of size fractions of anhydrous lactose The bulk and consolidation behaviour of pharmaceutical excipients belong to their important properties. Properties of five size fractions of anhydrous lactose having the particle size in the range of 1-400 µm were studied in this thesis. The measurement was carried out by using static and dynamic pharmacopoeial methods. The bulk density and the tapped density, the angle of repose were evaluated as well as the true density of particles by using the gas pycnometry. The mass flow rate through the orifice of a model conical hopper by the force of gravity was estimated for the individual size fractions. The discharge rate through the orifice having the diameter in a range of 0.6-1.5 cm was modelled with the Beverloo et al and Jones < Pilpel power regression equations; the precision of the flow rate prediction was about 3 %. The best bulk properties were detected for the particle size fraction 246 µm. The results of the evaluation of the consolidation dynamic during the tapping of powder bed permitted...
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A study of the compressibility and the properties of tablets from the coprocessed dry binder with mannitol for oral disintegrating tablets.
Lešková, Patrícia ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Candidate: Patrícia Lešková Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the diploma thesis: A study of the compressibility and the properties of tablets from the coprocessed dry binder with mannitol for oral disintegrating tablets This thesis deals with the study of directly compressible tableting materials and tablets with Ludiflash® , which was intended for ODT formulation. The effect of three lubricants was evaluated on the properties of tableting materials and tablets. Testing lubricants were magnesium stearate, calcium stearate and sodium stearyl fumarate in concentrations of 0,5 and 1%. Flow properties, compressibility, ejection force, tensile strength and disintegration time of the tablets were tested. Energy profile of compression process was used for the evaluation of compressibility. Lubricants did not improve the flowability of Ludiflash® . The total energy of compression increased with compression force. Its the highest values were at the tableting materials with 0,5% concentration of magnesium stearate and sodium stearyl fumarate, while the lowest values were at the tableting materials with 1% calcium stearate. The values of plasticity decreased with compression force and there was...
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A study of compressiblity and properties of tablets from coprocessed dry binder with manntol and croscarmellose sodium for orodispersible tablets.
Kamarýtová, Martina ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Martina Kamarýtová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of compressibility and properties of tablets from coprocessed dry binder with mannitol and croscarmellose sodium for orodispersible tablets. This thesis deals with the study of directly compressible tableting materials and tablets with Parteck® ODT, which is designed for orodispersible tablets. The effect of three lubricants on the properties of tableting materials and tablets is evaluated. Tested lubricants are magnesium stearate, calcium stearate and sodium stearyl fumarate in concentrations of 0,5 and 1 %. Flow properties, compressibility, ejection force, tensile strength and disintegration time of tablets are tested. The compressibility is evaluated by the energy profile of compression process. Lubricants did not improve the flowability of Parteck® ODT. The total energy of compression increased with compression force and highest values were at the tableting material with 0,5 % magnesium stearate. The values of plasticity decreased with compression force, highest values were at the tableting material with 0,5 % sodium stearyl fumarate. The ejection force increased with compression force, the...
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Study of bulk and consolidation properties of size fractions of anhydrous lactose
Dostálová, Eliška ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Supervisor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Ing. Hana Hurychová Student: Eliška Dostálová Title of Thesis: Study of bulk and consolidation properties of size fractions of anhydrous lactose The bulk and consolidation behaviour of pharmaceutical excipients belong to their important properties. Properties of five size fractions of anhydrous lactose having the particle size in the range of 1-400 µm were studied in this thesis. The measurement was carried out by using static and dynamic pharmacopoeial methods. The bulk density and the tapped density, the angle of repose were evaluated as well as the true density of particles by using the gas pycnometry. The mass flow rate through the orifice of a model conical hopper by the force of gravity was estimated for the individual size fractions. The discharge rate through the orifice having the diameter in a range of 0.6-1.5 cm was modelled with the Beverloo et al and Jones & Pilpel power regression equations; the precision of the flow rate prediction was about 3 %. The best bulk properties were detected for the particle size fraction 246 µm. The results of the evaluation of the consolidation dynamic during the tapping of powder bed permitted...
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Homogenization of powder blends using a high-speed mixer
Perďochová, Kristína ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Department of Pharmaceutical Technology Supervisor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: PharmDr. Karel Palát, CSc. Student: Kristína Perďochová Title of Thesis: Homogenization of powder blends using a high-speed mixer This work focuses on using a high-speed mixer for the powder mixing process in pharmaceutical technology. Shortened experimental plan was used to study the influence of three factors (mixing speed, mixing time and weight of the mixture) in order to achieve the overall homogenity of the mixture containing acetylsalicylic acid and microcrystalline cellulose. Individual samples were compressed into tablets. The homogenity of the mixture was evaluated using near infrared spectroscopy (NIR). The standard devations of the measured spectra were observed. The best results obtained from studied mixtures were achieved by a combination of mixing 150 g of mixture, rotational speed of 900 rpm and mixing time of 30 seconds.
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A study of directly compressible tableting materials and matrix tablets with polyvinyl alcohol.
Vildová, Lucie ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Lucie Vildová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis A study of directly compressible tableting materials and matrix tablets with polyvinyl alcohol This work evaluates and compares the properties of directly compressible tableting materials and matrix tablets containing the combination of α-lactose monohydrate and microcrystalline cellulose in the ratio of 3:1 in a physical mixture and in a coprocessed dry binder. Polyvinyl alcohol is used as the retarding agent at the concentrations of 30, 40 and 50 %. Tested parameters are compressibility, tensile strength of tablets and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Dissolution testing is performed using rotating basket method. The values of total energy of compression, plasticity and tensile strength of the tablets were higher in the tableting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. The dissolution behavior of tablets, which contained physical mixture or coprocessed dry...
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A study of directly compressible tableting materials and tablets with the retarding component containing polyvinyl acetate and povidone.
Fousová, Dominika ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical Technology Student Dominika Fousová Consultant PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis A study of directly compressible tableting materials and tablets with the retarding component containing polyvinyl acetate and povidone. Compressibility of directly compressible tableting materials used for manufacturing of prolonged release matrix tablets is being investigated in this thesis. Prosolv® SMCC 90 and MicroceLac® 100 were used as coprocessed dry binders. Kollidon® SR in concentration 20 % and 30 % as well as mixture of 10 % Kollidon® SR with Compritol® 888 ATO at the concentration of 10 % werechosen as retarding agents. Compressibility of each tableting blend was described using compression energy profile and tensile strenght of tablets. Rotating basket method was chosen for disolution testing. Values of all energies of the compression proces and plasticity were higher in the case of tableting materials with coprocessed dry binder Prosolv® SMCC 90. These tablets also showed higher tensile strenght. Tablets with 30 % of Kollidon® SR showed thehighest tensile strength and tablets with the combination of retarding agents Kollidon® SR and Compritol® 888 ATO showed the lowest tensile strength in the case...
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A study of directly compressible tableting materials and tablets with the coprocessed dry binder containing lactose, povidone and crospovidone.
Nguyen Thi, Thu Ha ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical technology Student: Nguyen Thi Thu Ha Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of directly compressible tableting materials and tablets with the coprocessed dry binder containing lactose, povidone and crospovidone. Thesis studies the coprocessed dry binder Ludipress® , which consists of α-lactose monohydrate, polyvinylpyrrolidone and crospovidone. Ludipress® was tested in the mixture with lubricants magnesium stearate and sodium stearyl fumarate in 0,5 % and 1 % concentration and with microcrystalline cellulose in 25 % concentration. Test focused on flowability, compressibility, tensile strength and disintegration time of tablets. Compressibility was evaluated by energy profile of compression in function of compression force. Ludipress® shows high friction therefore addition of lubricant is necessary. Lubricants improved powder flowability and compressibility; 0,5 % concentration of magnesium stearate is the most suitable. Higher concentration of lubricants decreased tensile strength of tablets. Disintegration time did not increase with compression force. Tablets with 1 % concentration of sodium stearyl fumarate had the longest time of disintegration. The addition of 25 %...
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