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Adherence to pharmacotherapy by idiopathic inflammatory bowel diseases
Červený, Petr ; Vlček, Jiří (advisor) ; Fendrich, Zdeněk (referee) ; Zbořil, Vladimír (referee)
Aim of the work The aim of the work was to analyze patient's adherence (compliance) to the pharmacotherapy of inflammatory bowel disease in Czech Republic, as well as to analyze quantity and character of potential drug interactions in medications of the tested kohort. Our aims were : 1. to analyze adherence to pharmacotherapy of IBD: o in the patients cohort followed up in the single IBD Unit (Gastroenterological Centre, the 4th Medical Department, Prague) o in the patients cohort followed up in a few gastroenterological ambulancies in the Czech Republic 2. to analyze potential drug interactions in medications of IBD patients Results 1. Adherence to pharmacotherapy of IBD in the patients cohort followed up in the single IBD Unit (Gastroenterological Centre of the 4th Medical department, Prague) 177 patients were enrolled in the study (84 male, 93 female, 117 CD, 60 UC). The patients evaluated their adherence to the pharmacological treatment in an interview. From 47 patients, treated by mesalazine, the urine sample for HPLC analysis of mesalazine was taken. The data was processed by descriptive statistics and factor analysis. 18.6 % of patients admitted they minimally once in the past voluntarily discontinuated their treatment, without their gastroenterologist's consent. A voluntary lowering of the...
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The analysis of management of drug related problems by community pharmacists during medicine dispensation
Kavříková, Lenka ; Vlček, Jiří (advisor) ; Macek, Karel (referee)
The analysis of management of drug related problems by community pharmacists during medicine dispensation Author: Mgr. Lenka Kavříková Consultant: Assoc. prof. RNDr. Jiří Vlček, CSc. Department of Clinical and Social Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Introduction: The role of the pharmacist in securing of safe medication practices is not in the Czech Republic yet well documented. Aim: Analysis of pharmacy practice during dispensing of drugs (types and frequency of interventions and solving drug-related problems) and the influence of pharmacist`s education on proper dispensing practice and identification of drug-related problems. Method: During two periods in 2006 was monitoring two pharmacists in dispensing activities in basic pharmacy located in municipality with 15,000 inhabitants. Between these two observed periods was inserted education seminar, which was built on the analysis of the cases identified in the first phase of the project. All the pharmacist`s interventions and information service to patients were documented. Data were recorded using Pharmastat program. Data were evaluated by frequency analysis, testing association between variables were performed by statistical software SPPS 15.0. Identified drug interactions were analysed using Thomson...
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ANTIBIOTIC CONSUMPTION ANALYSIS BASED ON HEALTH INSURANCE COMPANY DATA
Buriánková, Lenka ; Zimčíková, Eva (referee) ; Vlček, Jiří (advisor)
ANTIBIOTIC CONSUMPTION ANALYSIS BASED ON HEALTH INSURANCE COMPANY DATA Student: Buriankova L. Tutor: Vlcek J., Dept. of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Background: Overuse and misuse of antibiotics leads to increased resistance of microorganisms to antibiotics. There is a risk we will not have antibiotics effective against pathogenic microorganisms in future. It is therefore very important to make guidelines for rational prescribing and use of antibiotics. Aim: Analyze antibiotic consumption data package collected in given period depending on consumer age or sex. Analyze which group of doctor prescribes antibiotics in most cases. Analyze the most prescribed substances depending on different expression of consumption and compare obtained data with available data. Methods: Source of data is a database of employment insurance. The number of insurance clients was 129 699 in 2006 and 131 876 in 2007. Antibiotic use was evaluated, namely the group J01 of ATC system - Antibacterial drugs for systemic use. Data cover years 2006 and 2007. AISLP-CR, version 2008.4 is a database used for searching information about different drugs and substances. Obtained data were summarized in a database in Microsoft Excel. ATC / DDD system was...
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Rationaly Aspectof Antibioticotherapy in Patients treated with Dialysis.
Vrběcká, Radka ; Vlček, Jiří (advisor) ; Zemková, Marcela (referee)
Ždímalová R.: Analysis of consumption of antibiotics in patients treated with dialysis, Charles University in Prague, Faculty of Pharmacy, Department of social and clinical pharmacy, Hradec Králové 2009, 73 pages. Introduction and objective: This study observes consumption of antibiotics in patients treated with dialysis in The University Hospital of Hradec Králové in years 2006 and 2007. Pilot project investigate, which kind of antibiotics used dialyzed patients (DP) the most of all. Studies further compare information from two sets of DP from Czech Republic (Group I) and Lithuania (Group II) in specific aspects of antibiotic's consumption. Methodology: Retrospective analysis resulting from data evaluation from Nephris database of University Hospital of Hradec Králové by DP (2006&2007). Set of data of the Group II from Clinics of Kaunas Medical University - Lithuania was process by retrospective analysis too. GLMZ mode was used for statistical analysis. Results: Group I: from average number of 125 hospitalized patients were treated by antibiotics 71 (57%) patients. Both men and women have the same representation in the group, patients undergoing dialysis mostly in higher age, what has been discovered by mean age 66 years. From 71 patients treated with antibiotic was prescribed the most of all...
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Analysis of treatment of patients with epilepsy dispenzarized in University Thomayer's Hospital in Prague.
Frýdlová, Dana ; Vlček, Jiří (advisor) ; Kubová, Hana (referee)
Analysis of treatment of patients with epilepsy dispenzarized in University Thomayer's Hospital in Prague Student: Frýdlová D. Tutor: Vlček J., Tlustá E. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Background: Studies on antiepileptic drug utilization are important for evaluation of epilepsy treatment and risk of antiepileptic drugs (AEDs). Aim: To describe group of patients with epilepsy, AEDs utilization patterns and adverse drug reactions (ADRs) of AEDs. Methods: Data were retrieved from medical records in University Thomayer's Hospital in period 2005 - 2006. Epileptic outpatients (n = 97) aged over 16 years were considered for analysis. Results: The age ranged from 17 to 72 years (mean 55), 62 % were women. Partial seizures were diagnosed in 62 % of patients. 31 % of patients were more then 2 years without seizures, 39 % of patients had more then 12 seizures per year. More then half (65 %) of the patients were treated with polytherapy. Lamotrigin was the most commonly prescribed AED (20 %), followed by valproate (18 %) and carbamazepine (17 %). The most frequently prescribed AED in monotherapy was valproate, followed by lamotrigin, carbamazepine and levetiracetam. The ADRs were recorded in 41 patients. The most...
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2Adherence to Osteoporosis Treatment
Vytřísalová, Magda ; Vlček, Jiří (advisor) ; Horák, Pavel (referee) ; Macek, Karel (referee)
Literature search Introduction: Osteoporosis (OP) is an important non-communicable disease, the incidence of which is increasing. It is a systemic metabolic skeletal disease characterized by reduced bone mass and changes in bone tissue quality. These disorders increase the risk of fracture and consequently have a considerable impact on public health. OP affects primarily postmenopausal women, but has recently become a great concern in men as well. Among the most important preventive (and non-drug therapeutic) interventions are a diverse diet high in calcium, adequate physical activity, avoidance of exposure to toxic substances and fall prevention. Multiple therapeutic strategies are used in attempts to restore balance between the bone resorption and the bone formation. A first-line intervention is calcium and vitamin D supplementation. Specific drug therapies (anti-osteoporosis drugs) are classified according to the predominant mechanism of action into anticatabolic or antiresorptive drugs (bisphosponates, raloxifene, calcitonin) and formation stimulating, anabolic drugs (parathormones), and drugs with a dual mechanism of action (strontium-ranelate). The current treatment strategies reduce the risk of fracture by about half and have proved cost effective. As in other chronic asymptomatic diseases,...
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Knowledge of patients with diabetes mellitus about hypoglycaemia.
Hromádková, Lucie ; Vlček, Jiří (advisor) ; Matoulková, Petra (referee)
Nowadays, diabetes mellitus belongs to wide-spread diseases. 4-7% of population suffer from diabetes in developed countries and the number is increasing. Education of patients with diabetes mellitus ensures effective treatment and it contributes to the delay of diabetic complications. Therapy itself without correct and effective patient education can hardly lead to successful treatment. One of the frequent diabetic complications is hypoglycaemia, which can be fatal due to patient ignorance. The aim of this pilot study was to evaluate the degree of patient knowledge about hypoglycaemia, to monitor its distribution among patients and to analyze its possible risk factors. Cross-sectional observational study was used for the analysis. Data were obtained from structured direct interviews carried out among diabetic patients. The study was performed in Faculty hospital in Hradec Králové. Submission of patients into the study was random. Patients with diabetes mellitus types 1. and 2. visiting the diabetologic centre in Faculty hospital in Hradec Králové were included. Information was gained from 100 patients (109 addressed (92 %)). The average age of respondents was 54 years and men prevailed (55 %). The number of diabetic patients of type 2 was two times higher than the number of diabetic patients of type...
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