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National Repository of Grey Literature 13 records found  previous11 - 13  jump to record: Search took 0.01 seconds. 
Stability studies of monoclonal antibody nimotuzumab modified with chelator DOTA radiolabelled with lutetium-177 ([177Lu]Lu-hR3(p-SCN-Bn)DOTA)
 Petřík, Michal ; Lázníčková, Alice (advisor) ; Kubíček, Vladimír (referee)
The higher expressivity of the gene for the receptor of epidermal growth factor (EGF) and consequently higher number of receptors (EGFR) on the surface of cells is closely linked with the tumour proliferation of these cells and with poor prognosis for patients. For such reason the EGFR became one of the main objectives in the therapy of tumours. Nimotuzumab (also known as h-R3) is humanized monoclonal antibody which blocks receptor for epidermal growth factor. The object of this thesis was to determinate radiochemical purity of this antibody conjugated with bifunctional chelator DOTA and marked by luthecium, possibly purification of this antibody and consequently determination of its stability in different environments. In acetate buffer pH = 7, in an environment of the surplus of competitive ligand EDTA and in plasma of rats. Adequate analytic methods were used for these tasks: high-efficiency liquid chromatography, gel permeation chromatography and chromatography on thin layer. The results of the thesis demonstrated that this way of modification for further radiolabelling is not appropriate for large protein structures such as Nimotuzumab
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Logistika nakládání s nebezpečnými odpady z legislativně-procesního pohledu
 Petřík, Michal
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Možnosti nakládání s biodegradabilním odpadem
 Petřík, Michal
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National Repository of Grey Literature : 13 records found   previous11 - 13  jump to record:
See also: similar author names
1 Petrík, Marcel
4 Petrík, Marek
12 Petrík, Michal
1 Petrík, Milan
1 Petřík, Martin
4 Petřík, Michael
1 Petřík, Miloš
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