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Soil management of large investment projects on the example of the industrial zone Kolín - Ovčáry
Bejblová, Klára ; Šefrna, Luděk (advisor) ; Kuklík, Miloslav (referee)
The thesis deal with the soil sealing and the rehanding with the uncovering of soil cultural layers. This problem is describe on the example of the industrial zone Kolín - Ovčáry. In the thesis there is the evaluation of the soil characteristics and their changes in areas where due to the trensfer of the cultural layer was created completely new structure of soil cover compact of soil units with artificial stratigraphy of profile. For this area the new classification subsumtion is suggested. The overall impacat of the soilsealig and implementation of the uncovering of soil cultural layers, despite of local incerase of soil fertility parameters, we evaluate as the degradation of soil cover.
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Importance of trombophilic mutations in clinical genetic.
Vavrušková, Klára ; Kuklík, Miloslav (advisor) ; Černá, Marie (referee)
Trombophilia means an increased disposition to creation of trombs. Health complication incurred as a consequence of hypercoagulation can be very serious. When a trombophilic mutation is found at a patient, it brings necassity of thrombosis - control in risk situations (e.g. pregnancy, operation) for the rest of the patient's life. There were filed 300 people (206 women and 94 men) with trombophilic mutations into my study of clinical signification of trombophilic mutations. These people were examinated in years 2008 - 2010. Most of positive medical findings - 266 people, were recorded in the area of MTHFR (C677T i A1298C) mutations. There were less findings in the field of FV Leiden and FII prothrombin mutations. Multipath trombophilic mutations were found at 99 patients. I accordance with foreign literature, our results advert to clinical consequences of trombophilic mutations like: repeated spontanious aborts, cerebrovascular akcident (CA), ischaemic heart disease (IHD), thrombosis, flebothrombosis, pulmonary embolism, varicose veins, aseptic necrosis of hip bone, arterial sclerosis and aortic stenosis. Mutations MTHFR C677T and MTHFR A1298C we found mainly at patients with CA, IM and IHD. Leiden mutation was most often found at patients with thrombosis, flebothrombosis and pulmonary embolism. We...
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Gilbetr syndrome
Šimáková, Eva ; Kuklík, Miloslav (advisor) ; Kučerová, Mária (referee)
The mail focus of this thesis is to assess a genealogical frequency of homo- and heterozygotes for a mutation in a promotor region of UGT 1A1 gene. This mutation is typical for Gilbert's syndrome. It explains a genesis, symptoms, pathology and also a therapy of this syndrome. It discusses a possibly protective effect of this polymorphic mutation that might result in a lower incidence of vascular diseases (myocardial infarction, stroke, atherosclerosis, pulmonary embolism). An important contribution is also an attenuation of stress due to hyperbilirubinaemia. This thesis was worked out in a cooperation with GENVIA Ltd.
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