National Repository of Grey Literature 25 records found  previous11 - 20next  jump to record: Search took 0.00 seconds. 
Different metabolic pathwazy of the origin of hyperhomosysteinemia
Přistoupilová, K. ; Přistoupil, T. I. ; Navrátil, Tomáš ; Heyrovský, Michael ; Šenholdová, Z. ; Kohlíková, E. ; Petr, M.
Our voltammetric method of estimation of thiodiglycolic acid (TDGA) in urine was used in case of a woman suffering from rare inborn inability to metylate homocysteine (HoCySH). The aim of this pilot study was to shed more light on the interrelationship among vitamin B.sub.12./sub., folates, and betaine used for her cure. On the basis of the achieved results we were able to modify our earlier published metabolic scheme. It comprises 3 metabolic pathways starting from serine, and three metabolic pathways starting from HoCySH.
Voltammetric Determination of one of Styrene Metabolites - Phenylglyoxylic Acid - in Urine Using Graphite Composite Electrode
Navrátil, Tomáš ; Shanmugam, K. ; Šenholdová, Z. ; Heyrovský, Michael ; Surovcová, H.
Phenylglyoxylic acid is metabolized in human body from vinylbenzene (styrene) (from which polystyrene is produced). Presented work deals with determination of this metabolite in human urine using carbon composite electrode.
Relationships between Metabolism of Homocysteine and Physiological Formation of Thiodiglycolic Acid
Přistoupilová, K. ; Přistoupil, T. I. ; Šenholdová-Dlasková, Z. ; Navrátil, Tomáš
Thiodiglycolic acid (TDGA), structurally S(CH2COOH)2, is a part of the metabolic pathway used by the human organism to remove dicarbon units produced in catabolic processes TDGA origanates from glycolate and glutathione (GSH). The latter is dependent on the release of cysteine from homocysteine under the influence of vitamins folate and B12.
Thiodiglycolic Acid in Urine
Navrátil, Tomáš ; Šenholdová-Dlasková, Z. ; Heyrovský, Michael ; Přistoupilová, K. ; Přistoupil, T. I.
Thiodiglycolic acid (TDGA) is a physiological intermediate of the metabolism of cysteine which originates from homocysteine transformation. Estimation of increased levels of TDGA in urine reveals indicates intoxication of workers in chemical industry by halogenated organic solvents. Therefore our cheap and simple analytical method of TDGA determination is a contribution to toxicological control in industry.
Determination of Cystine, Cysteine and Homocysteine in Biological Matrix
Bašová, Pavlína ; Navrátil, Tomáš ; Šestáková, Ivana ; Novotný, Ladislav ; Šenholdová-Dlasková, Z.
In order to determine cystine, cysteine and homocysteine contents separately in a mixture of these compounds in real urine samples from patients suffering from cystinuremia and homocistinuremia, three voltammetric methods were tested: Brdička reaction, reduction of their complexes with copper ions and cathodic reduction of cystine. In all cases the hanging mercury drop electrode was used.
Metabolic Causes of Thiodiglycolic Acid Formation and Importance of its Determination
Šenholdová-Dlasková, Z. ; Navrátil, Tomáš ; Přistoupil, T. ; Přistoupilová, K.
Thiodiglycolic acid (TDGA), is one of the normal products of human metabolism, and occurs at low concentrations in urine. An increased level of TDGA in urine is a sensitive indicator of human organism exposure to some physiologically active or toxic substances, gases and vapors (vinylchloride monomer, etc.). The attention was paid to suggestion and explanation of the metabolic pathways related to thiodiglycolic acid in non-exposed organism.
Determination of thiodiglycolic acid concentration in case remethylation disorder
Navrátil, Tomáš ; Šenholdová, Z. ; Heyrovský, Michael ; Přistoupilová, K. ; Přistoupil, T. I. ; Surovcová, H.
The new simple voltammetric method we described recently was useful in determining thiodiglycolic acid (TDGA) levels in urine samples. The article deals with revealing of time dependencies of the concentration levels of this metabolic product in healthy persons as well as persons suffering from various diseases. The corresponding metabolic processes are described.
Voltammetric Determination Phenylglyoxylic Acid in Urine Using Graphite Composite Electrode
Navrátil, Tomáš ; Šenholdová, Z. ; Shanmugam, K. ; Barek, J. ; Surovcová, H.
Phenylglyoxylic acid is metabolized in human body from vinylbenzene (styrene) (from which polystyrene is produced). Presented work deals with determination of this metabolite in human urine using carbon composite electrode. In the article are compared the results of analysis of the certified material (urine), achieved on the mercury and on the carbon composite electrodes.

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