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Modulation of body fat content by targeting the lipid metabolism of adipose tissue
Šponarová, Jana ; Kopecký, Jan (advisor) ; Konvalinka, Jan (referee) ; Drahota, Zdeněk (referee)
CONCLUSIONS 1. Induction of obesiý resistance in mice by transgenic expression of UCP1 in white fat can be explained by a metabolic switch ínadipocýes, due to depressíon oť celluiar energy charge, in situ activaÍion of AMPK, down- regulation ofadipogenic genes and increase in lipid oxidation. 2. AMPK cascade is involved in the fat depot-specific metabolic responses in various fat depots to starvation. Activation of the cascade occurred in epididymal but not in subcutaneous fat in mice. The activation of AMPK in adipocytes might represent an important mechanism by which body fat stores are regulated and may contributes to regional differences in the metabolic properties ofadipose tissue depots. Dietary EPA and DHA reduce development of obesity induced in mice by high fat diets, in part due to counteracting increase in tissue cellularity, particularly in epididymal íat.Low EPA/DHA ratio potentiates the anti- adipogenic efíect. Dietary EPA and DHA induce a metabolic shift in white adipose tissue by up-regulating genes for mitochondrial proteins, including their regulatory genes PGCIa and NRF-I, and increase B-oxidation while depressing lipogenesis, preferentially in the epididymal fat in the abdomen. 3. 4. J. 21
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Effects of n-3 polyunsaturated fatty acids, rosiglitazone, low caloric diet and environmental pollutants: obesity and related disorders
Kuda, Ondřej ; Kopecký, Jan (advisor) ; Bendlová, Běla (referee) ; Pravenec, Michal (referee)
4. CONCLUSIONS Conceming the specific aims of the thesis, the following conclusions may be formulated: l.Additionalbeneficia|effectsofthecombinedfieatmentbyn_3PUFAof marine origin and anti-diabetic drug rosiglitazone on obesity and related disorders were proven in mice fed high-fed diet. In comparison with either n- 3 PUFA or TZD effects alone, the combined treatment was more potent in amelioration of the following adverse pheÍrotypes: a. body weight, body weight gain and body lipid content; b. dYsliPidaemia; c. muscle insulin resistance demonstrated as enhanced muscle glycogen synthesis; obesity-associated inflammation of adipose tissue; and inaddition,additiveinductionofadiponectinwasfound,especiallyits multimeric form, which induces insulin sansitivity' These results on mouse modet suggest possible application for human medicine, where fish oil concentrates may enhance efficacy ofthe treatment byTZD,and reduce the risk of the adverse effect of the TzD-therapy' 2. Relatively specific induction oflipid oxidation by n-3 PUFA in the intestine was found, which may be important for e'g' anti-obesity and hypolipidemic effects ofthese liPids. 3. Changes in adiponectin concentration as well as distribution of its multimeric forms as a result oflow caloric diet were found in human patients' 4. Association between...
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Control circuits of railway lift
Kopecký, Jan ; Lažek, Tomáš (referee) ; Huták, Petr (advisor)
This master thesis deals with the mechanical and electrical design of the drive of the inclined construction lift. Individual components are selected in the design. Furthermore, a theoretical research is carried out regarding wireless modules and logic controllers. The selection of sensors is made and the method of retrieving signals from sensors and converting them into iputs the control circuits is also outlined. A program is written in Arduino IDE that wirelessly controls the motion of a motor via variable frequency drive.
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determination of kinetic parameter of reactions using DSC
Kopecký, Jan ; Kouřil, Miloslav (referee) ; Jan, Vít (advisor)
The master thesis deals with DSC measurments a calculation of kinetic parameters. In the theoretical part, iron alotropy is briefly described, followed by a description of the DSC analysis itself. The thesis also includes division and derivation of isoconversional methods for calculating the activation energy. In the experimental part, a series of measurments is perfomed on pure iron prepared by Cold Spray method. In the paper the influence of deformation on the Curie temperature of the magnetic transformation in -Fe and transformation > is investigated. The activation energy is calculated for transformation > for different degrees of deformation. The degree of deformation is monitored by channeling contrast.
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