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Nanofibrous Membranes as Drug Delivery Systems
Vrbata, Petr ; Doležal, Pavel (advisor) ; Vetchý, David (referee) ; Podzimek, Štěpán (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical technology Candidate: Mgr. Petr Vrbata Supervisor: Doc. RNDr. Pavel Doležal, CSc. Title of Doctoral Thesis: Nanofibrous membranes as drug delivery systems Nowadays, nanofibrous membranes are very quickly developing systems with proportions in nanometre scale. They are intensively studied and used in many technical disciplines, mostly thanks to their unique properties, among them great surface area to volume as a highlight. Their use in the field of biomedicine and pharmacy as drug delivery carriers, wound dressings and tissue engineering scaffolds is currently a topic of great interest. The doctoral thesis deals with newly formulated drug loaded nanofibrous membranes made of several selected polymers with diverse properties produced by electrospinning technology for large-scale production. The purpose was an experimental investigation and demonstration of potential benefits from application of nanofibrous membranes to selected application sites and dosage forms. The prepared membranes were evaluated by scanning electron microscopy and differential scanning calorimetry that proved successful incorporation of the drugs into the structure of the polymeric nanofibers. Moreover the measurements proved that the...
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Evaluation of the influence of filler sort and lubricant type and concentration on the parameters of the compaction equation
Ondrejček, Pavel ; Rabišková, Miloslava (advisor) ; Vetchý, David (referee) ; Bělohlav, Zdeněk (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of pharmaceutical technology Candidate Mgr. Pavel Ondrejček Supervisor prof. PharmDr. Miloslava Rabišková, CSc. Title of Doctoral Thesis Evaluation of the influence of filler sort and lubricant type and concentration on the parameters of the compaction equation This thesis is dealing with an evaluation of the compaction process of pharmaceutical excipients and their mixtures. The effect of the filler type, lubricant type and its concentration on the parameters of the compaction equation developed by Assoc. Prof. RNDr. Milan Řehula, CSc. is studied. Microcrystalline cellulose Avicel PH-200, lactose Lactochem Fine Crystals and calcium hydrogen phosphate dihydrate Emcompress were used as model fillers. These fillers of similar particle size were selected because of different bonding mechanism and varying course of the compaction process. Fillers were evaluated individually and then in their blends with lubricants magnesium stearate, sodium stearylfumarate and Syloid, i.e. modified colloidal silica in concentration 0,5 and 1 %. Moisture content and flow properties were determined in individual fillers. Particle size distribution, scanning electron microscope pictures and specific surface area measurements were...
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Study of static and dynamic flow properties of pharmaceutical excipients
Hurychová, Hana ; Šklubalová, Zdeňka (advisor) ; Vetchý, David (referee) ; Zámostný, Petr (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Candidate: Ing. Hana Hurychová Supervisor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Doctoral Thesis: Study of static and dynamic flow properties of pharmaceutical excipients Flow properties are among the most significant characteristics of pharmaceutical materials. Recent modern technologies allow preparation of particles with modified surface properties and flow behaviour for the conventional as well as new excipients. In this work, the static (compressibility index, Hausner ratio, angle of repose, shear testing) and dynamic (flow rate, avalanche testing) flow properties of a wide variety of excipients, their particle size fractions and selected model mixtures were evaluated. In particular, attention was paid to modelling of the flow rate by the equation prospectively suitable for use in the standardization of flow testing in pharmaceutical technology. The power equation in which the equation parameter is a direct prediction of the flow rate through an orifice having a unit diameter is recommended. The basic granulometric characteristics of particles were completed with the particle fractal dimension (pDF) and the bulk fractal dimension (bDF). Although a relatively strong correlation between the...
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Nanofibrous Membranes as Drug Delivery Systems
Vrbata, Petr ; Doležal, Pavel (advisor) ; Vetchý, David (referee) ; Podzimek, Štěpán (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical technology Candidate: Mgr. Petr Vrbata Supervisor: Doc. RNDr. Pavel Doležal, CSc. Title of Doctoral Thesis: Nanofibrous membranes as drug delivery systems Nowadays, nanofibrous membranes are very quickly developing systems with proportions in nanometre scale. They are intensively studied and used in many technical disciplines, mostly thanks to their unique properties, among them great surface area to volume as a highlight. Their use in the field of biomedicine and pharmacy as drug delivery carriers, wound dressings and tissue engineering scaffolds is currently a topic of great interest. The doctoral thesis deals with newly formulated drug loaded nanofibrous membranes made of several selected polymers with diverse properties produced by electrospinning technology for large-scale production. The purpose was an experimental investigation and demonstration of potential benefits from application of nanofibrous membranes to selected application sites and dosage forms. The prepared membranes were evaluated by scanning electron microscopy and differential scanning calorimetry that proved successful incorporation of the drugs into the structure of the polymeric nanofibers. Moreover the measurements proved that the...
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Nanofibrous Membranes as Drug Delivery Systems
Vrbata, Petr ; Doležal, Pavel (advisor) ; Vetchý, David (referee) ; Podzimek, Štěpán (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical technology Candidate: Mgr. Petr Vrbata Supervisor: Doc. RNDr. Pavel Doležal, CSc. Title of Doctoral Thesis: Nanofibrous membranes as drug delivery systems Nowadays, nanofibrous membranes are very quickly developing systems with proportions in nanometre scale. They are intensively studied and used in many technical disciplines, mostly thanks to their unique properties, among them great surface area to volume as a highlight. Their use in the field of biomedicine and pharmacy as drug delivery carriers, wound dressings and tissue engineering scaffolds is currently a topic of great interest. The doctoral thesis deals with newly formulated drug loaded nanofibrous membranes made of several selected polymers with diverse properties produced by electrospinning technology for large-scale production. The purpose was an experimental investigation and demonstration of potential benefits from application of nanofibrous membranes to selected application sites and dosage forms. The prepared membranes were evaluated by scanning electron microscopy and differential scanning calorimetry that proved successful incorporation of the drugs into the structure of the polymeric nanofibers. Moreover the measurements proved that the...
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Evaluation of the influence of filler sort and lubricant type and concentration on the parameters of the compaction equation
Ondrejček, Pavel ; Rabišková, Miloslava (advisor) ; Vetchý, David (referee) ; Bělohlav, Zdeněk (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of pharmaceutical technology Candidate Mgr. Pavel Ondrejček Supervisor prof. PharmDr. Miloslava Rabišková, CSc. Title of Doctoral Thesis Evaluation of the influence of filler sort and lubricant type and concentration on the parameters of the compaction equation This thesis is dealing with an evaluation of the compaction process of pharmaceutical excipients and their mixtures. The effect of the filler type, lubricant type and its concentration on the parameters of the compaction equation developed by Assoc. Prof. RNDr. Milan Řehula, CSc. is studied. Microcrystalline cellulose Avicel PH-200, lactose Lactochem Fine Crystals and calcium hydrogen phosphate dihydrate Emcompress were used as model fillers. These fillers of similar particle size were selected because of different bonding mechanism and varying course of the compaction process. Fillers were evaluated individually and then in their blends with lubricants magnesium stearate, sodium stearylfumarate and Syloid, i.e. modified colloidal silica in concentration 0,5 and 1 %. Moisture content and flow properties were determined in individual fillers. Particle size distribution, scanning electron microscope pictures and specific surface area measurements were...
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Evaluation of the influence of filler sort and lubricant type and concentration on the parameters of the compaction equation
Ondrejček, Pavel ; Rabišková, Miloslava (advisor) ; Vetchý, David (referee) ; Bělohlav, Zdeněk (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of pharmaceutical technology Candidate Mgr. Pavel Ondrejček Supervisor prof. PharmDr. Miloslava Rabišková, CSc. Title of Doctoral Thesis Evaluation of the influence of filler sort and lubricant type and concentration on the parameters of the compaction equation This thesis is dealing with an evaluation of the compaction process of pharmaceutical excipients and their mixtures. The effect of the filler type, lubricant type and its concentration on the parameters of the compaction equation developed by Assoc. Prof. RNDr. Milan Řehula, CSc. is studied. Microcrystalline cellulose Avicel PH-200, lactose Lactochem Fine Crystals and calcium hydrogen phosphate dihydrate Emcompress were used as model fillers. These fillers of similar particle size were selected because of different bonding mechanism and varying course of the compaction process. Fillers were evaluated individually and then in their blends with lubricants magnesium stearate, sodium stearylfumarate and Syloid, i.e. modified colloidal silica in concentration 0,5 and 1 %. Moisture content and flow properties were determined in individual fillers. Particle size distribution, scanning electron microscope pictures and specific surface area measurements were...
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