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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
mmunohistochemical analysis of the inhibitory glycine and GABAB receptors in the MNTB
 Trojanová, Johana ; Tureček, Rostislav (advisor) ; Druga, Rastislav (referee) ; Vyklický, Ladislav (referee)
Properties of glycine (GlyR) and GABAB (GABABR) receptors were studied in the adult rat medial nucleus of the trapezoid body (MNTB). MNTB belongs among brainstem auditory nuclei. Prevailing cell type in the MNTB is the principal cell (PC). Each PC receives two types of synaptic inputs. Excitatory input originating at contralateral anteroventral cochlear nucleus (AVCN), forms a giant glutamatergic nerve terminal, calyx of Held (CH). Inhibitory inputs are brought by glycinergic and GABAergic fibers of unclear origin. Synaptically released GABA and glycine modulate excitatory synaptic transmission in MNTB via receptors expressed by presynaptic and postsynaptic neurons. The goal of our work was to elucidate both the subcellular distribution and subunit composition of the receptors, thereby extend our knowledge of the function of the receptors in the MNTB. We used immunohistochemical staining methods. The receptors were labelled by specific antibodies localized in the nervous tissue by means of fluorescence or electron microscopy. The experimental work consisted of three phases. During the first phase we revealed that GlyRs in the MNTB form two distinct populations. Postsynaptic receptors form α1β heteromeric clusters on somatodendritic parts of PCs. These clusters colocalize with glycinergic endings...
Detailed record
mmunohistochemical analysis of the inhibitory glycine and GABAB receptors in the MNTB
 Trojanová, Johana ; Tureček, Rostislav (advisor) ; Druga, Rastislav (referee) ; Vyklický, Ladislav (referee)
Properties of glycine (GlyR) and GABAB (GABABR) receptors were studied in the adult rat medial nucleus of the trapezoid body (MNTB). MNTB belongs among brainstem auditory nuclei. Prevailing cell type in the MNTB is the principal cell (PC). Each PC receives two types of synaptic inputs. Excitatory input originating at contralateral anteroventral cochlear nucleus (AVCN), forms a giant glutamatergic nerve terminal, calyx of Held (CH). Inhibitory inputs are brought by glycinergic and GABAergic fibers of unclear origin. Synaptically released GABA and glycine modulate excitatory synaptic transmission in MNTB via receptors expressed by presynaptic and postsynaptic neurons. The goal of our work was to elucidate both the subcellular distribution and subunit composition of the receptors, thereby extend our knowledge of the function of the receptors in the MNTB. We used immunohistochemical staining methods. The receptors were labelled by specific antibodies localized in the nervous tissue by means of fluorescence or electron microscopy. The experimental work consisted of three phases. During the first phase we revealed that GlyRs in the MNTB form two distinct populations. Postsynaptic receptors form α1β heteromeric clusters on somatodendritic parts of PCs. These clusters colocalize with glycinergic endings...
Detailed record

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