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The effect of solvent on disintegration time of liquisolid systems in the form of capsules
Helerová, Ladislava ; Vraníková, Barbora (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: doc. PharmDr. Barbora Vraníková, Ph.D. Consultant: MSc. Andreas Niederquell Student: Ladislava Helerová Title of Thesis: The effect of solvent on disintegration time of liquisolid systems in the form of capsules According to the literature, the resulting liquisolid (LS) powders may be formulated into the form of tablets, pellets or hard gelatine capsules. However, the available resources about liquisolid systems do not consider possible interactions between the used excipients and capsule shell. Carriers can adsorb the water from the gelatine capsule and hence cause its brittleness, while the solvent can penetrate the capsule shell and thereby affects its integrity and properties. For these reasons, LS capsules containing mixtures of the carrier Neusilin® US2 (NUS2) with different amounts of propylene glycol (PG), polysorbate 80 (PS 80) or the cyclosporine A (CysA) dispersions in these solvents were prepared and tested. The disintegration time in three dissolution media, differential scanning calorimetry (DSC) and infrared spectroscopy (IR) were evaluated to study the changes in the capsule properties. The obtained results showed that the disintegration time of LS capsules was prolonged...
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