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National Repository of Grey Literature

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Effect of sunitinib on the expression of iNOS in normotensive and hypertensive rats Mertlíková, Veronika ; Nachtigal, Petr (advisor) ; Fikrová, Petra (referee) Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Veronika Mertlíková Consultant: Doc. PharmDr. Petr Nachtigal, Ph.D. Title of rigorous thesis: Effect of sunitinib on the expression of iNOS in normotensive and hypertensive rats. The aim of the thesis is to describe the expression of iNOS in the vessel wall of spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats after long-term administration of cytostatic sunitinib. As an experimental model inbred males of SHR rats and normotensive WKY rats were used. They were divided into 2 groups - experimental and control. Sunitinib in drinking water (10mg/ kg per day) was administered to experimental group of rats while the control group of rats recieved only drinking water. In the experimental group of SHR rats, sunitinib was administered for 8 weeks and then after 5 days break it was administered for next 8 weeks. In the experimental group of WKY rats, sunitinib was administered for 8 weeks and then after 5 days break it was administered for only 2 weeks due to weight loss and toxicity symptoms. Immunohistochemical methods were used for detection of iNOS expression, specifically the ABC method. No significant differences of iNOS expression in the... Detailed record

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