National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 

Warning: Requested record does not seem to exist.
Electron bifurcation - a new phenomenon in bioenergetics
Bazger, Jan ; Hrdý, Ivan (advisor) ; Ženíšková, Kateřina (referee)
Electron bifurcation is a type of enzymatic catalysis that involves the reduction of two spatially separated electron acceptors of different redox potentials by a single electron donor. A characteristic feature of this type of catalysis is the gain of a product with a higher free energy than that of the original electron donor. The energy for this endergonic reduction is obtained from a second, exergonic electron transport reaction pathway. Since 2008, when the observation of this biochemical process, previously known only from the Q-cycle in complex III, was extended by the discovery of flavin- based electron bifurcation, a total of 12 flavoproteins catalyzing this process have been described. The use of flavin-based electron bifurcation has so far been observed mainly in anaerobic prokaryotes, such as acetogens or methanogens, which live in environments with low-energy substrates. For these organisms, the possibility to reduce ferredoxin or flavodoxin, the electron acceptors of the endergonic part of the reaction, is an important physiological advantage, since these molecules can be used as electron donors for the subsequent reduction of other low-potential acceptors under favourable thermodynamic conditions. Phylogenetic analyses that give a comprehensive overview of the overall possible spread...

Interested in being notified about new results for this query?
Subscribe to the RSS feed.