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Effect of selected bicyclic monoterpenes on the activity and expression of antioxidant enzymes in human liver
Křížová, Anna ; Boušová, Iva (advisor) ; Szotáková, Barbora (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Anna Křížová Supervisor: doc. PharmDr. Iva Boušová, Ph.D. Title of diploma thesis: Effect of selected bicyclic monoterpenes on the activity and expression of antioxidant enzymes in human liver Monoterpenes are plant secondary metabolites, which are used as flavourings or aromas in the food industry due to their smell and flavour. They also play an irreplaceable role in the cosmetic and pharmaceutical industry. Monoterpenes are substances with a wide spectrum of biological activities. They exert, for example, antimicrobial, anti- inflammatory, antioxidant, hypotensive, and analgesic effects. In addition to the positive effects of these substances, some cases of their toxic effects in various organs were also observed, mostly in the liver. Monoterpenes also affect the activity and expression of antioxidant enzymes. The aim of this thesis was to determine the effect of five selected bicyclic monoterpenes, (+)-camphor, (-)-camphor, (-)-fenchone, camphene, and (-)-α-thujone, on the activity and expression of antioxidant enzymes. Of those enzymes, glutathione-S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT) were studied. At...
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