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Evaluation of antimicrobial effectiveness of new quaternary ammonium salt compounds
Suk, Ondřej ; Kovařík, Miroslav (advisor) ; Janďourek, Ondřej (referee)
Author: Ondřej Suk Title: Evaluation of antimicrobial effectiveness of new quaternary ammonium salt compounds Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Study program: Pharmacy Background: The aim of the work was to evaluate antimicrobial activity of newly proposed and prepared quaternary ammonium salts. Methods: Broth microdilution method was used to measure antimicrobial activity of 8 new substances divided into three structure groups on 8 bacteria strains: Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Yersinia bercovieri, Klebsiella pneumoniae, Klebsiella pneumoniae ESBL positive and multiresistant Pseudomonas aeruginosa. Results: Out of the 3 structure groups, the highest antimicrobial potential was found with some methylmorpholine salts and benzylimidazole substituted salts. Generally, the substances were, as supposed, more efficient with the Gram-positive bacteria tribes than with the Gram-negative ones. No bactericidal effect of these substances in the concentration measured was found on the strain of multiresistant Pseudomonas aeruginosa. Conclusions: The Gram-positive strains tested are more sensitive towards the tested substances than the Gram-negative ones. In comparison with some...
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