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Celiac disease in childhood and adherence to gluten-free diet
 Číhová, Anna ; Frühauf, Pavel (advisor) ; El-Lababidi, Nabil (referee)
Basis: Celiac disease is a systemic autoimmune disease caused by gluten intolerance in genetically predisposed individuals that occurs in both children and adults. The presence of gluten in the diet results in the intestinal inflammation, crypt hyperplasia and villus atrophy in the predisposed individuals and consequently nutrient malabsorption. Celiac manifestations include a diverse spectrum of gastrointestinal and non-gastrointestinal disorders. The only treatment that leads to the normalization of the intestinal mucosa and the disappearance of problems is a lifelong, strictly gluten-free diet. Objective: Two objectives were chosen for this work. The first objective was to compare the levels of antibodies and thereby the compliance to the gluten-free diet of patients diagnosed by the biopsy and the non-biopsy procedure. The second objective was to compare the somatic parameters (weight, height and BMI) of all 170 individuals with the celiac disease, with the general population, especially the compliant and non-compliant patients with the general population, and the two groups. Methodology: In the practical part of this work, the chosen method was an anonymous collection of data from medical records. All findings that were collected were registered and compared and the statistics were analysed by...
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