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Optimization of tablet coating.
Brokešová, Jana ; Mrvová, Zdenka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Supervisor: Consultant: Ing. Zdenka Mrvová Mgr. Matěj Kovář Student: Jana Brokešová Title of Thesis: Optimization of tablet coating Tablet coating represents an important procedure in pharmaceutical technology. The coating can protect an active pharmaceutical ingredient from negative environmental conditions as well as ensure the drug release at a specific time and a specific site in the organism. Generally, the main types of tablet coating are sugar and film coating. As the sugar coating has a number of disadvantages such as a time-consuming production process, the difficult process standardization, the impossibility to produce a modified release mechanism, is nowadays rarely being used in pharmaceutical companies. This work deals with the replacement of sugar coating with film coating technology for the multivitamin product Spofavit®. During the pilot batch, the commercial coating mixture Nutraficient® Food Supplement Coating, Opadry AMB was applied on two types of tablet cores: the original composition tablet cores and the modified ones with added lactose. The weight variation, hardness, friability and disintegration properties were tested. After processing the results of the pilot batch, a...
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