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Formulation and (trans)dermal application of imiquimod
Rudecká, Kateřina ; Švecová, Barbora (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Mgr. Kateřina Rudecká Consultant: PharmDr. Barbora Školová, Ph.D. Title of Thesis: Formulation and (trans)dermal application of imiquimod. Imiquimod (IMQ) is a compound of the class of heterocyclic imidazoquinolines. It exhibits significant immunomodulatory effects after topical dermal application, thus it is used advantageously in the treatment of various viral or neoplastic skin diseases. The traded preparation Aldara® containing 5% of the active substance IMQ has, despite its undeniable benefits in treatment, also a number of negative features: the price, the need for single use packets, side effects... The aim of this work was to formulate a stable dosage form for dermal administration of lower IMQ content (1%) and to compare the penetration and permeation rate of IMQ to human skin in vitro. To improve those qualities, permeation accelerants were used. Experiments were carried out in Franz's diffusion cells on human skin, with the aim of creating conditions as close as possible to those physiological. Using adhesive tapes, individual layers of the uppermost skin section (stratum corneum) were stripped, epidermis was separated from dermis and the treated tissue from the untreated one. The...
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