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Synthesis of microRNA-21 inhibitors
Vosátka, Jan ; Marek, Jan (advisor) ; Nováková, Veronika (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Jan Vosátka Supervisor: PharmDr. Jan Marek, Ph.D. Consultant: Prof. Morten Grötli, Marta P. Carrasco, Ph.D. Title of diploma thesis: Synthesis of microRNA-21 inhibitors Nowadays structures which negatively suppress some pathological processes in the organism have been revealed, for example small molecules - microRNAs. For various diseases, such as cancer or cardiac fibrosis, specific types of microRNAs, which participate in pathological growth of these affected tissues, have been discovered. MicroRNAs, as a hot issue, has resulted in focusing on the creation of inhibitors of these small structures in different stages of their genesis. For this work miR- 21 occurring in some kinds of cancer and cardiovascular disease, mainly in cardiac fibrosis, has been used. The assays showed that the suppressing of miR-21 positively influences these pathological processes and 4-(2-phenylhydrazinyl)-N-prop-2-ynyl-benzamide was determined to be the appropriate inhibitor. This inhibitor contains azobenzene's moiety which allows the compound to interconvert between two isomers upon irradiation. In this way, this compound can be considered a photoswitchable molecule. The main goal of this...
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