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Breath condensate in the diagnosis of lung diseases
Řihák, Vladimír ; Pauk, Norbert (advisor) ; Salajka, František (referee) ; Musil, Jaromír (referee)
Univerzita Karlova v Praze, 3. lékařská fakulta Disertační práce MUDr. Vladimír Řihák Kondenzát vydechovaného vzduchu v diagnostice plicních nemocí Breath condensate in the diagnostics of lung diseases Školitel: doc. MUDr. Norbert Pauk, Ph.D. SUMMARY Introduction: Examination of exhaled breath condensate is offered as a new, noninvasive diagnostic method in lung diseases. It has been described about 200 markers, which were verified in the condensate, some more, some less developed. The gold standard of examination is exhaled nitric oxide and its metabolites. Other markers are studied in the diagnosis of COPD or pulmonary fibrotic processes. The aim is to use them not only for diagnosis, but also for monitoring dinase, or preventive measures. Methods: 124 patients were examined during 3 years at The University Clinics of Pneumology and Thoracic Surgery in Prague Bulovka and the Pulmonary Department of the Regional Hospital of Tomas Bata in Zlín. Among them were assembled subgroups: a) the health of nonsmokers, b) smokers without any symptoms of respiratory illness with normal lung function tests, c) asthmatics with evidence of uncontrolled disease treatment, d) in asthmatics who had controlled disease, e) patients with exacerbated COPD, f) COPD patients without evidence of exacerbation, g) patients with...
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