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Formulation of Polyester Nanoparticles using Variants of Emulsion Methods
Nosková, Veronika ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Charles University of Prague, Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Candidate Mgr. Veronika Nosková Consultant Doc. RNDr. Milan Dittrich, CSc. Title of Thesis: Formulation of polyester nanoparticles using variants of emulsion methods The experimental plan of the thesis was intended to the study of three preparation methods of biodegradable in water insoluble nanoparticles made from polyester drug carriers. Following three methods were realized: The method of spontaneous emulsification by turbulent solvent flow from inner into outer emulsion phase was the first, the classic emulsion solvent distribution and evaporation method by the using of high speed homogenizer was the second one, and the method based on polymer solution emulsification by sonication was the last one. As model polyester drug carrier was selected terpolymer of DL-lactic acid, glycolic acid and tripentaerythritol. As solvents of this polymer were choosen commonly used acetone, methylformate was tested as in this field novel ingredient. As emulsifying agents were evaluated anionic sodium laurylsulfate, cationic cetrimide (cetyltrimethylammonia bromide), and nonionic grafted copolymer of dimethicone and polyethylene glycol. The parameters of nanoparticles measured were mean intensity diameter,...
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