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Development of immune response to the Hymenoptera venom allergens during specific allergen immunotherapy
Hrabánková, Eva ; Kučera, Petr (advisor)
Order of ants and wasps ( Hymenoptera ) counts a hundred thousand species of insects (only on the lives of our around 15,000 kinds ) 1 . Some individuals have a stinging venom apparatus that they primarily used to defend against the enemy or stun kořisti1 , 2 and 3 stings or bites One can manifest in different ways. Not too often, but severe or even fatal complication of systemic allergic reactions. System allergen immunotherapy respective insects ( " Specific Allergen Immunotherapy " - SAIT ), abbreviated poison Immunotherapy ( " Venom Immunotherapy " - VIT) is the only causal therapy , anti- of a serious or life -threatening IgE -mediated anaphylactic reaction to following stabbing relevant type hmyzu4 . Its purpose is to induce long-term immunological tolerance (specific hyposensitization) to systemically administered alergenům5 . Initial attempts at VIT has been carried out in the 20s of last century , the initially used whole body extracts ( "whole body extreacts " - WBEs ) were due to comparable efficacy to placebo , replaced in the 70s poisonous extracts , which are used for diagnosis and therapy dodnes3 . The mechanism of induction of immunological tolerance through SAIT is complex and not yet fully understood . Probably induces the formation of the so-called " Blocking " IgG antibodies , reduces...
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