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New trends in antiphospholipid syndrome in pregnancy treatment
 Kroupová, Monika ; Andělová, Kateřina (advisor)
Antiphospholipid syndrome is a systemic autoimmune disease characterised by presence of the antiphospholipid antibodies in serum. The diagnosis of APS including aPL measured in solid-phase immunoassays (ELISA) as anticardiolipin antibodies or detected in phospholipid dependent clotting tests as lupus anticoagulans. Positiv APS is characterised by prolonged coagulation times. In Pregnancy is APS characterised by placental insufficiency, pre-term delivery, pre-eclampsia and intrauterine growth retardation. He interferes in trofoblast growth and invasion and hampers in trofoblast function. At present is used low-molecular-weight heparin in combination with low-dose aspirin. Non-pregnant patiens with history of thrombosis are usually treated by warfarin to keep an APTT between 2-3.
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