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Antimicrobial effect of antidepressants. II.
 Jánošík, Petr ; Jílek, Petr (advisor) ; Vejsová, Marcela (referee)
We've investigated the in vitro synergistic antibacterial potential of selective serotonin reuptake inhibitors (paroxetine and fluoxetine) and antibiotics (represented by tetracycline and nalidixine). Activity has been measured against four bacterial CCM strains (Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus) and eight tetracycline-resistant strains (Escherichia coli and Pseudomonas aeruginosa). Synergy tests were performed using checkerboard method. We've observed growth or growth inhibition of bacteria, marked the "border" points area out and converted these points to values of relative concentrations in a graph. According to the under-graph area we've counted the CRIC. This coefficient has shown us the type of antibacterial interaction of the SSRI and antibiotics. In most cases we have observed addition of antimicrobial activity of the SSRI and antibiotics (either CCM strains or tetracycline-resistant strains), sometimes indifference and in rare cases also synergism (tetracycline- -paroxetine and tetracycline-fluoxetine against E. coli 2468, nalidixine-fluoxetine against S. aureus CCM, tetracycline-fluoxetine against Pseudomonas aeruginosa 421). We have observed a decrease of resistance to tetracycline only in one case (tetracycline-paroxetine against E....
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