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Study of Fluorescence of Selected Benzimidazoles
Richtrová, Monika ; Lázníčková, Alice (referee) ; Kubíček, Vladimír (advisor)
The influence of used solvents on fluorescence of seven selected benzimidazoles (reduced flubendazole, albendazole, 2-aminobenzimidazole, carbendazim, benomyl, thiabendazole a oxibendazole) is studied in this thesis. It was found, that solvents, used in liquid chromatography as mobile phases, influence the fluorescence of individual benzimidazoles in a very diverse ways. The shape of the fluorescence spectra is very strongly dependent on the structure of a benzimidazole. The obtained results can serve as starting points during a development of chromatographic methods for a benzmidaloles determination with the fluorimetric detection. In the other part of the thesis, a derivatization of hydrolyzed mebendazole with 7- chloro-4-nitrobenzo-2-oxa-1,3-diazole is studied as a way enabling a fluorescence detection of this substance. Unfortunately, the obtained results are not promising.
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