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Study of antioxidant and cytoprotective effects of intracellular iron chelators in catecholamine-induced cardiomyocyte injury
 Koubková, Lucie ; Šimůnek, Tomáš (advisor) ; Boušová, Iva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Biochemical Sciences Candidate: Lucie Koubková Supervisor: Profa . Dra . Natércia Teixeira Profa . Dra . Georgina Correia da Silva Doc. Pharm.Dr. Tomáš Šimůnek, Ph.D. Title of diploma thesis: Evaluation of anti-aromatase activity of isoflavones from biotransformed soya Breast cancer belongs to the most frequently diagnosed cancers in women. Approximately 60% of breast cancer is hormone-dependent containing estrogen receptors and requiring estrogen for tumour growth. Estrogens are able to promote transcription of genes involved in cell proliferation. Aromatase is responsible for the final step of estrogen biosynthesis and its inhibition has been considered as an important target for the treatment of estrogen-dependent breast cancer. Soya is a source of phytoestrogens, such as genistein and daidzein, which are thought to be effective in breast cancer prevention. However, the mechanisms associated with this effect are not fully understood. In this study we evaluated the effects of a soya extract containing genistein and daidzein on aromatase activity. Our results demonstrated that this extract had the ability to inhibit aromatase in a dose-dependent manner in placental microsomes and also in the MCF-7aro breast cancer...
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