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Regulation of parameters of biological activity of colorectal cancer
 Svobodová, Šárka ; Svačina, Štěpán (advisor) ; Beneš, Zdeněk (referee) ; Vízek, Martin (referee)
Colorectal cancer (CRC) has been considered to be the most frequent cancer disease based on prevalence rate and mortality rate. The earlier diagnostics provides the better therapy outcomes. Many new laboratory tests and techniques for early detection of CRC have been developed recently. Not many of the can be used for daily routine clinical practice so far. The aim of this dissertation thesis was to measure a large spectrum of parameters in patients with early stage of CRC and to evaluate them for routine practice, as they may play a potential regulatory role in cancer development and control process. (...) Our finding of a very low sensitivity of tumor markers CEA and CA 19-9 for CRC in early stages I.-III. is fully corresponding with literature data. When monitoring some parameters during chemotherapy course we have found that only TK seems to be important for adjuvant therapy control, but TK and CEA and CA 19-9 can be used of palliative therapy monitoring. TK increases after every chemotherapy cycle but it decreases before the beginning of the following cycle if the therapy is successful. But it is continuously increasing if the therapy is unsuccessful. CEA and CA 19-9 are permanently within reference intervals in adjuvant therapy. Before palliative therapy beginning all the parameters are elevated and...
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