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název v anglickém jazyce není uveden
 Šenolt, Ladislav ; Pavelka, Karel (advisor) ; Rovenský, Jozef (referee) ; Pokorný, Jaroslav (referee)
Rheumatoid arthritis (RA) and osteoarthritis (OA) represent the most common forms of musculosceletal disorders that affect diarthrodial joints, lead to joint damage and disability. Extra-articular manifestations accompanied the joint disease only in RA. Diagnosis of both conditions most commonly bears on the conventional radiography. Mostly in OA, radiographic changes often occur late in the disease and are largely irreversible. Molecular markers could reflect joint damage, inflammation, or immune response. Current investigation revealed potential uses of molecular markers, ranging from understanding pathogenesis of the diseases to predicting and monitoring the outcome of the treatment. The aim of the thesis was to analyze several biochemical markers in serum, synovial fluid and synovial tissue samples from patients with RA and OA. and to evaluate their diagnostic and predictive values as well as their contribution to the pathogenesis of the diseases. We found increased serum pentosidine concentrations in OA patients that were ol a predictive value of the joint space narrowing in OA of the knee joint and correlation between pentosidine and cartilage oligomeric matrix protein (COMP) in synovial fluid that make pentosidine one of the new potential biomarkers of the OA. Scrum level of COMP was similar among...
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