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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Equinní rekurentní uveitida
 PÍCHOVÁ, Dominika
ERU significantly impacts horse breeding not only in Europe. This disease, which can lead to recurrent inflammation of the uveal tract of the eye, is the main cause of blindness in horses. Its management and treatment require a careful and proactive approach from horse owners and veterinary ophthalmologists to minimize its effects and improve the quality of life for affected animals. Prevention, early diagnosis, and innovative treatment methods can play a key role in combating ERU. The aim of the bachelor's thesis was to evaluate available data on the occurrence and treatment of ERU in various horses divided by age, gender, and type of housing through a questionnaire survey.
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The role of microorganisms and other factors in the process of autoimmune uveitis
 Dušek, Otakar ; Heissigerová, Jarmila (advisor) ; Rozsíval, Pavel (referee) ; Krulová, Magdaléna (referee)
The role of microorganisms and other factors in the process of autoimmune uveitis Abstract The aim of this work was to gain new knowledge about the influence and the mechanisms of the effect of microorganisms in the process of autoimmune uveitis. A mouse model of experimental autoimmune uveitis (EAU) was used and the influence of oral broad-spectrum antibiotic, i.e. metronidazole, as well as probiotic bacteria Escherichia coli O83:K24:H31 (EcO) nad Escherichia coli Nissle 1917 (EcN) were tested in preventive and therapeutic regimens. The grade of inflammation was assessed clinically in vivo and histologically post mortem. Immunological analysis of lymph nodes and Peyer's patches were performed. Evaluation of the effect of metronidazole proved significant reduction of inflammatory activity in both regimes - intitiation 1 week or 2 weeks before the EAU induction. In case of probiotics, protective effect was proved only in case of live EcN administered 2 weeks before or from the time of EAU induction. Its protective effect was accompanied with decreased interphotoreceptor retinoid-binding protein (IRBP)-specific T-lymphocyte response in the sentinel lymph nodes of the site of immunization 7 days after the induction of EAU and cervical lymph nodes as soon as there were apparent clinical signs of intraocular...
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