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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
The impact of maternal-fetal microchimerism on the development of the offspring's immune system
 Malinská, Nikola ; Černý, Jan (advisor) ; Balounová, Jana (referee)
Maternal-fetal microchimerism is a phenomenon in which maternal cells migrate to the offspring's tissue during both pregnancy and breastfeeding. These cells are mainly leukocytes and stem cells. These maternal cells have functional potential in the offspring and influence, among other things, the development of their immune system. The main cell population detectable in various tissues of the offspring are T lymphocytes. These maternal T lymphocytes not only have effector function, but also influence the development of the offspring's T lymphocytes in the thymus or maturation of offspring's B lymphocytes in the lymph nodes. Migration of maternal leukocyte also leads to transfer of immune memory through generations. Maternal microchimerism is also capable of balancing immunodeficiencies of the offspring. Maternal cells expressing IL-2 were detected in mice deficient in IL-2 and maternal IgG secreting plasma cells were found in offsprings deficient in B cell. This work is focused on the influence of maternal cells transported within maternal microchimerism on the development of the offspring's immune system as well as the effector functions of maternal cells migrating through the placenta and breast milk to the offspring.
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Congenital disorders in horse
 PRANTLOVÁ, Veronika
The task of this thesis is to elaborate literary study of congenital disorders incidence by horses. At the beginning, there are summarized problems of congenital disorders in general, such as origin of the disorders and the forming factors. Further, the most common or the most severe equine congenital disorders, considering specific prevalence depending on the breed, are specified. The thesis also contents the incidence of congenital disoders by other kinds of domestic animals. At the end the practical breeder´s advices are summarized.
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