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National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Nádorová imunoterapie založená na mechanismech vrozené imunity a studium možnosti zvýšení její účinnosti úpravou nádorového prostředí
 MASÁKOVÁ, Kamila
The aim of this thesis was to study how to increase effectiveness of cancer immunotherapy based on synergy of compounds stimulating phagocytosis and TLR agonist. Tumor microenvironment was modified by enzymes, which catalised conversion of lactate to pyruvate or acetate. It was monitored effect of enzymes on tumor size, survival of experimental mice and cytotoxicity on tumor cells.
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Nádorová imunoterapie založená na synergii agonistů TLR a ligandů stimulujících fagocytózu. Posouzení spoluúčasti získané imunity.
 PAĎOUKOVÁ, Lucie
The aim of this thesis is to improve the therapeutic effect of the immunotherapy based on the synergy of TLR agonists with phagocytosis stimulating ligands. Furthermore, this thesis is focused on the information transfer to the specific immunity, as well as it pursues the study of the specific immunity relevance during cancer immunotherapy.
Detailed record
Studium nádorové imunoterapie založené na instalaci ligandů fagocytárních receptorů na nádorové buňky a objasnění probíhajících procesorů
 CAISOVÁ, Veronika
Immunotherapy became a very promising approach for cancer therapy. Tumor cells are eliminated using the body's own immune system with minimal negative effect on healthy tissue. This thesis is focused on immunotherapy based on activation of innate immunity, specifically on intratumoral application of ligands stimulating phagocytosis and Toll-like receptor ligands. This therapeutic approach was tested in several types of tumor mouse models, such as melanoma B16-F10, pancreatic adenocarcinoma, and pheochromocytoma. The composition of the therapeutic mixture as well as the application schedule were optimized in our studies. Subsequently the underlying mechanisms involved in tumor elimination during this therapy were investigated.
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