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Brown adipose tissue and its positive effects
Máchová, Magdaléna ; Horníková, Daniela (advisor) ; Haasová, Eliška (referee)
Brown adipose tissue (BAT) is a specialized type of adipose tissue that plays an important role in non-shivering thermogenesis which is induced most often after cold acclimation. However, many studies have also highlighted the role of BAT in influencing the cardiovascular system and thus obesity, diabetes mellitus type 2, atherosclerosis, and insulin resistance. BAT has a protective effect against oxidative stress and recent studies suggest that it also has a potential therapeutic relevance for the treatment of cancer and osteoporosis, while it may also play a role in the body's immunomodulatory effects. Key words: brown adipose tissue, non-shivering thermogenesis, cold acclimation, β-adrenergic receptors, therapeutic potential
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Gamma-delta T lymphocytes in adipose tissue
Sztoláriková, Adéla ; Krulová, Magdaléna (advisor) ; Pačes, Jan (referee)
T lymphocytes are a unique type of T lymphocytes which, because of their innate-like qualities, belong to the so-called innate lymphocytes. Although they are a relatively rare population of T lymphocytes in peripheral blood, they are enriched in many peripheral tissues where they participate in immune responses to infectious pathogens and cell transformation. In addition, they play a role in the development of several autoimmune disorders. Recently, non- immune functions of T lymphocytes in tissue repair and tissue homeostasis have also been emphasized. This work focuses on the characterization of T lymphocytes, especially those residing in adipose tissue. T lymphocytes regulate adipose tissue homeostasis and overall energy metabolism. The roles of T lymphocytes under physiological and non-physiological conditions are described, including their impact on the development of obesity and metabolic syndrome. The possible applications of these lymphocytes in the treatment of these diseases are also briefly mentioned.
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