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Adenosine methylation (m6A) in plant mRNA
Holoborodko, Anastasiia ; Růžička, Kamil (advisor) ; Náprstková, Alena (referee)
In eukaryotic organisms, there are known more than 200 internal post-transcriptional modifications of RNA. N6-methyladenosine (m6 A) is the most common modification in mRNA. In plants, m6 A affects many aspects of mRNA processing, such as mRNA splicing, alternative polyadenylation, export from the nucleus, its overall stability or translation. Adding, removing, and perceiving of m6 A are handled by protein complexes containing methyltransferases (writers), demethylases (erasers), and m6A-binding proteins (readers), respectively. Dynamic regulations of m6 A have a significant effect on plant development. Also, m6 A exerts its role in response to abiotic stress and viral infection. This thesis summarizes current knowledge on m6A in plants in light of the latest advances in animal experimental models.
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