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Possibilities of physiotherapy for acquired temporomandibular joint dysfunction
RADOŠOVÁ, Kristýna
This bachelor thesis deals with the issue of acquired temporomandibular joint disorders and focuses on the possibilities of influence from the perspective of physiotherapy. Any change in the function of this constantly stressed joint affects individuals throughout the day. The temporomandibular joint participates in activities such as speaking or chewing, which we perform from early hours, making its behavior beyond physiological properties a very pressing matter. Changes arise due to various causes, often of non-uniform nature. The aim of the thesis is to map these acquired dysfunction causes. The theoretical part consists of basic anatomical knowledge of the jaw joint, masticatory, and hyoid muscles. Furthermore, it includes a chapter on kinesiology, etiological factors, and possible causes of acquired dysfunction, as well as specific TMJ disorders. The last chapter discusses treatment options both surgically and conservatively. The main goal of the practical part is to assess the effect of the performed physiotherapeutic intervention. The research form is qualitative, and the sample consists of three women aged 22-23, whose data are processed into three case studies. Participants experienced symptoms such as jaw joint pain, occurrence of auditory phenomena, or changes in lower jaw mobility. Individually tailored therapy involves influencing symptoms and their reduction, with emphasis on home autotherapy. The final therapy evaluation is based on comparing the initial and final kinesiological analyses.
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Role of transcription factors MEIS in the origin and development of the neural crest
Fábik, Jaroslav
Unique to the vertebrate embryo, neural crest cells represent a multipotent cell population that migrates throughout the body and gives rise to a multitude of different types of cells and tissues. Cranial neural crest cells populate the developing pharyngeal arches and establish skeletogenic condensations that generate the future bones and cartilages of the face and neck. Moreover, these cells send out and receive signals from adjacent tissues of non-neural crest origin, such as the mandibular epithelium and muscle precursor cells. Such reciprocal interactions give rise to organs and structures, for instance, to the tongue. The aim of this work was to elucidate the roles of homeodomain-containing MEIS transcription factors in neural crest cells and in craniofacial development, by using a mouse model with conditional inactivation of Meis2 gene in neural crest cells. We show that transcription factor MEIS2 is expressed in the medial region of the developing mandible and in the developing tongue. Conditional Meis2 inactivation using the Wnt1-Cre2 mouse strain caused mandible and tongue hypoplasia, and ectopic bone formation at the expense of tongue development. These mandibular arch anomalies were accompanied by the loss of Hedgehog signaling in the mandibular epithelium, expanded RUNX2 expression in...
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Role of transcription factors MEIS in the origin and development of the neural crest
Fábik, Jaroslav ; Machoň, Ondřej (advisor) ; Buchtová, Marcela (referee) ; Procházka, Jan (referee)
Unique to the vertebrate embryo, neural crest cells represent a multipotent cell population that migrates throughout the body and gives rise to a multitude of different types of cells and tissues. Cranial neural crest cells populate the developing pharyngeal arches and establish skeletogenic condensations that generate the future bones and cartilages of the face and neck. Moreover, these cells send out and receive signals from adjacent tissues of non-neural crest origin, such as the mandibular epithelium and muscle precursor cells. Such reciprocal interactions give rise to organs and structures, for instance, to the tongue. The aim of this work was to elucidate the roles of homeodomain-containing MEIS transcription factors in neural crest cells and in craniofacial development, by using a mouse model with conditional inactivation of Meis2 gene in neural crest cells. We show that transcription factor MEIS2 is expressed in the medial region of the developing mandible and in the developing tongue. Conditional Meis2 inactivation using the Wnt1-Cre2 mouse strain caused mandible and tongue hypoplasia, and ectopic bone formation at the expense of tongue development. These mandibular arch anomalies were accompanied by the loss of Hedgehog signaling in the mandibular epithelium, expanded RUNX2 expression in...
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