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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Modulation of blood-testis barier by Sertoli cells
 Faltýnková, Petra ; Filipp, Dominik (advisor) ; Krulová, Magdaléna (referee)
Sertoli cells in testicles are the main building blocks of the seminiferous tubules where they facilitate the process of spermatogenesis. Although, the Sertoli cells were discovered by Enrico Sertoli more than a 150 years ago, there is still much to discover about their development and functions. The Sertoli cells are critical for the development of germ cells by the provision of hormonal, nutritional and physical support as well as by engulfment of their emerged waste. Since such intimate nurturing interactions with developing spermatocytes require a stable and isolated environment, Sertoli cells themselves create a protected endoluminal compartment sealed off by the blood-testis barrier (BTB). The BTB is a junctional complex formed between adjoining Sertoli cells and serves as an impermeable barrier in the paracellular space. However, spermatogonial stem cell initiating the spermatogenesis lies in front of the BTB closure, hence the developing spermatocytes have to pass through the BTB which is tightly regulated to maintain tissue homeostasis. BTB also exhibits immunological functions, because it can either sequester germ cell-specific antigens from the systemic circulation or release them behind the BTB. The aims of my thesis are to provide a brief overview of Sertoli cell functions in...
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The role of Fbxo38 ubiquitin ligase in mouse spermatogenesis
 Zobalová, Eliška ; Čermák, Lukáš (advisor) ; Stopka, Pavel (referee)
Cullin-dependent ubiquitin ligases are responsible for the regulation of most cellular processes. Despite their mutated forms being the cause of many human diseases, their physiological roles are not sufficiently described. In the presented results, we focused on the physiological role of ubiquitin ligase SCFFBXO38 (SKP1-CULLIN1-FBXO38), whose mutated forms are responsible for the progression of distal neuropathy. Preparation of mouse model deficient in FBXO38 revealed that homozygous pups were born in a lower than expected ratio. Animals were growth-retarded, both at the level of the whole organism and individual organs, especially the liver and testes. Males with a deletion in the Fbxo38 gene had significantly lower reproductive capacity, which was associated with lower production of mature sperm and pathological changes in the structure of seminiferous tubules. We found that the FBXO38 protein is functionally expressed in Sertoli cells responsible for regulating spermatogenesis and seminiferous tubules integrity. Detailed analysis of spermatogenic populations revealed a defect at the level of spermatocyte differentiation. The dynamics of this differentiation depend on the hematotesticular barrier functional integrity formed by the intercellular junctions of Sertoli cells. We confirmed that the...
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