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Exercise-based predictors of atrial fibrillation recurrence in patients undergoing catheter ablation.
Mátych, Martin ; Pešl, Martin (referee) ; Hejč, Jakub (advisor)
Atrial fibrillation (AF) is the most frequently treated heart arrhythmia. Radiofrequency catheter ablation is a treatment option with a success rate ranging from 60 % to 80 % for paroxysmal AF. This work aimed to determine parameters associated with AF recurrence to identify high-risk patients. Data from 98 patients who underwent pulmonary vein isolation were analyzed. Out of these patients, 19 experienced AF recurrence. Exercise and echocardiographic parameters differed significantly between the recurrence and non-recurrence groups and were used in regression analysis. Peak oxygen consumption (pVO2) was found to be a strong predictor of AF recurrence after adjusting for gender and age (hazard ratio 0.43). Four parameters were identified as the ideal combination in multivariable analysis: pVO2, septal peak late diastolic mitral annulus velocity, post-exercise systolic blood pressure, and left atrial volume index. These findings highlight the importance of stress and echocardiographic parameters in predicting the success of ablation procedures.
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Exercise-based predictors of atrial fibrillation recurrence in patients undergoing catheter ablation.
Mátych, Martin ; Pešl, Martin (referee) ; Hejč, Jakub (advisor)
Atrial fibrillation (AF) is the most frequently treated heart arrhythmia. Radiofrequency catheter ablation is a treatment option with a success rate ranging from 60 % to 80 % for paroxysmal AF. This work aimed to determine parameters associated with AF recurrence to identify high-risk patients. Data from 98 patients who underwent pulmonary vein isolation were analyzed. Out of these patients, 19 experienced AF recurrence. Exercise and echocardiographic parameters differed significantly between the recurrence and non-recurrence groups and were used in regression analysis. Peak oxygen consumption (pVO2) was found to be a strong predictor of AF recurrence after adjusting for gender and age (hazard ratio 0.43). Four parameters were identified as the ideal combination in multivariable analysis: pVO2, septal peak late diastolic mitral annulus velocity, post-exercise systolic blood pressure, and left atrial volume index. These findings highlight the importance of stress and echocardiographic parameters in predicting the success of ablation procedures.
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Gender equality, women's participation in the post-conflict society, and civil war recurrence
Drevená, Katarína ; Aslan, Emil (advisor) ; Kotvalová, Anna (referee)
A large amount of academic literature demonstrated that intrastate conflicts often occur in countries that have already experienced civil war. This reoccurring pattern forced several researchers to analyze which factors contribute and which lower the risk of war recurrence. This master thesis focuses on the civil war recurrence through the lenses of gender. I will argue that higher gender equality could lower the risk that intrastate conflict will reoccur. If the countries are organized by norms of gender inequality, the same treatment is reproduced towards the other groups within society. On the other hand, more gender-equal societies may transform these relationships into the same tolerant relationships with those who are perceived as different and foreign in the country. Moreover, socialization and the way children have been raised play an important role in how they will behave as adults. Less patriarchal societies with a lower focus on the norm of dominance create space for norms of tolerance, respect, peace, freedom, and equality which has a pacifying effect on the behavior of the state and people within it. Therefore, I will hypothesize that the higher women's political, economic, and social participation, the longer the duration of peace after the civil war. Large-N quantitative analysis in...
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Ověřování předpokladů modelu proporcionálního rizika
Marčiny, Jakub ; Kulich, Michal (advisor) ; Zvára, Karel (referee)
The Cox proportional hazards model is a standard tool for modelling the effect of covariates on time to event in the presence of censoring. The appropriateness of this model is conditioned by the validity of the proportional hazards assumption. The assumption is explained in the thesis and methods for its testing are described in detail. The tests are implemented in R, including self-written version of the Lin- Zhang-Davidian test. Their application is illustrated on medical data. The ability of the tests to reveal the violation of the proportional hazards assumption is investigated in a simulation study. The results suggest that the highest power is attained by the newly implemented Lin-Zhang-Davidian test in most cases. In contrast, the weighted version of the Lin-Wei-Ying test was found to have inadequate size for low sample sizes.
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