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Customized hybrid bioscaffolds for bone regeneration
Šťastný, Přemysl ; Šupová,, Monika (oponent) ; Pabst, Willi (oponent) ; Trunec, Martin (vedoucí práce)
The doctoral thesis titled “Customized hybrid bioscaffolds for bone regeneration” is divided into two parts. The first part tries to reveal the theoretical background of a bone-to-implant interaction and the current state of the art in the research of calcium phosphate materials and calcium phosphate-based implants for bone tissue engineering. The customization concept and a careful selection of phase composition represents two main points of the second, experimental, part of the doctoral thesis. The customization concept in this work is not only just a simple shape and dimension optimization process of an implant, but additionally attention is paid to the microstructural features, phase composition and phase distribution allowing the rational design and a production of tailor-made materials for dinstinct medical applications. Cellular and biological responses to the ceramic materials were evaluated both by in-vitro and in-vivo tests and were discussed against the material composition and the microstructural features. The doctoral thesis shows how a fundamental understanding of physical and chemical properties of the material under question can help to design implants material with an outstanding biological response. The in-vivo application of the customized implant and its comparison with the current gold standard bone graft material – bone autograft is a unique and valuable outcome of the doctoral thesis.

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