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The effect of therapeutical ultrasound and metalic nanoparticles on carcinoma cells
Kalužová, Adéla ; Rozman, Jiří (referee) ; Bernard, Vladan (advisor)
This thesis focuses on the research of an effect of ultrasound and nanoparticles on cancer cells. In the literature search there the applications of ultrasound field in the interaction with aplication of metallic nanoparticles to viability of cancer cells are described, on the basis of in vitro experiments‘ performance. The purpose of metallic nanoparticles‘ application should be a possible reinforcing of its antitumor effect thanks to the presence of ultrasound field. In next part of the literature search there are included the technical performance of devices, their indications and contraindications, parameters of ultrasound fields and application of metallic nanoparticles. The metallic nanoparticles have been becoming a part of the human’s life more and more, that is why it’s necessary to deal with these miniature particles at a higher level. The aim of this thesis is to suggest the ways of resolution based on the principle of sounding of cells with the ultrasound field of suitable parameters and in combination with the application of metallic nanoparticles with a successive performance of the cell viability tests. The viability was determinated by the MTT assay test. Another part of this work is the measurement of parameters of this zone by means of a submersible needle hydrophone, for a better understanding of the ultrasonic zone. In the final part of this work there is necessary the statistical evaluation of the measured data of the experiments carried out and the discussion of the results obtained.
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The role of a nurse at general practitioner's office for children and adolescents in connection to prevention of testicular cancer
NESPALOVÁ, Jana
Theory background Testes are two male reproductive glands located in the scrotum and separated protective sheath of dense connective tissue. They play major role in spermatogenesis and hormone production. They also represent secondary gender symbols and therefore are important for the personality forming of young individuals. Testicular cancer stand for about 1- 1.8% of all malignant tumour diseases in males and occur most often between 15- 35 years of age. This bachelor's work gives information on the anatomy and physiology of testes, the risk factors and causes for the occurrence of testicular cancer, and also about the symptoms and diagnostics. This thesis also deals with the role the nurse has in general practitioner's office for children and adolescents regarding the prevention of testicular cancer, preventive check-ups and self-examination. Work aim First aim of this work is to map the role of the nurse in general practitioner's office for children and adolescents regarding the prevention of testicular cancer. The research question posed was: What is the role of the nurse in general practitioner's office for children and adolescents regarding the prevention of testicular cancer? Second aim was to find out about the awareness on testicular cancer in boys 15-19. First hypothesis says: Awareness about the prevention of testicular cancer varies with age. Second hypothesis: Self-examination of testes changes with age. Used methods Qualitative research was used for the first part of the assignment, while a questionnaire and method of deep dialogues with the nurses working at general practitioner office for children and adolescents in South Bohemia was conducted for the second part. The dialogs were recorded on a dictaphone and then transcribed word for word. In the second part quantitative research was used through a method of questioning and technique of non-standardised questionnaire. The questionnaire was filled in by boys aged 15-19 living in South Bohemia. The parameter test Anova, a type of scattering analysis, was used on the data. "Its basis lies in the total scattering of the followed variable being divided into scattering within individual selections and scattering between them. If the scattering between the selections is improbably large it points towards significant influence of factor a (Budíková, 2010, s. 181)." Results The transcribed dialogs were analysed by open coding, by the pen and paper method. Five categories were defined: Education, testicular cancer, testes examination, patient dispensary. Subcategories with major data encoded, were assigned to each category. Analysis of the non-standardised questionnaire gave rise to ten resulting graphs with respondent answers. The graphs were consequently described. First hypothesis saying that the knowledge about the prevention of testicular cancer changes with age was not proven. The second hypothesis saying that the process of self-examination changes with age was not proven either. Conclusions The first research part proves that nurses working in general practitioner office for children and adolescents do educate the patient on this subject. The respondent possessed basic information on the subject of prostatic cancer and stated that testes examination is conducted in the surgeries. Scientific literature for this subject was recommended by only two of nine respondents. The respondents stated that testes examination and education about the subject of testicular cancer is conducted, although the second part of the research showed that the boys are almost not at all familiar with the subject. Furthermore, testicular examination was not conducted for most of them at the practitioner's office. The second part of research showed that the boys aged 15-19 let possess insufficient information on the prevention of testicular cancer. Most had almost no knowledge on what is involved in such prevention.
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Radiotherapy of breast cancer
TRAKALOVÁ, Barbora
Diagnosis code C50 represents malignant neoplasm of breast. It is the most frequent tumour disease in women. In 2009, 5975 cases were newly diagnosed in women in the Czech Republic and 1607 women died of this disease. There exist many risk factors which can cause tumour such as hereditary disposition, age, menses, menopause and other factors. At the same time, we can influence many factors and so prevent the disease. Prevention is also important, whether in the form of self - investigation of breast or mammography screening, which is recoverable by insurance from the age of 45. Treatment of breast carcinoma includes a lot of medical modalities such as surgical, hormonal and biological treatment, chemotherapy and radiotherapy. This thesis deals in more details with radiotherapy which is irreplaceable in treatment of this disease. Radiotherapy is a treatment of malignant and benign tumours by means of ionising radiation. In order to treat patients with radiotherapy, a team of doctors and radiologists shall create an individual radiation plan for them including the exact target volume, critical organs, radiation technology, fractionation and particular radiation exposure, radiation position and many other data necessary to accurate irradiation. A technology of two tangential fields is the most applied technology at breast cancer treatment. This technology is also applied in Nemocnice České Budějovice a.s. where I have created a file of 60 patients with breast carcinoma treated on oncology department in the year 2011. There have been used 536 verification images on the whole, it means 1608 evaluation. In course of treatment a patient should have an identical radiation position, which is reached with irradiation and fixation aids. However, from various reasons small or bigger deviations from the optimal position happen and therefore a possibility of irradiation of another volume than the required target one can occur. It is necessary to be aware of the fact that during a treatment of oncology patients there can often appear change of weight, change of body shape of a patient and at advanced stages even also change of physical state and movability of a patient. Therefore large deviations can happen in patients with breast carcinoma namely for example in case of breast deformation or abnormal loss of weight due to the treatment. In Nemocnice České Budějovice a.s., the maximum allowed deviation for vertical, lateral and longitudinal axis is stated 0,7 cm and for rotation 3°. I have noticed the acquired deviation values from verification images into a chart and consequently into a figure where are shown the average deviations and frequencies of these deviation in particular axes for each radiation field. The biggest deviation has happened in vertical axis and the average deviation in that axis was 0,29 cm. The maximum allowed deviation was exceeded only at 3 %, so at 45 deviation from the total evaluation. This thesis should prove the fact that verification images enable to prevent possible errors during radiotherapy. This hypothesis has been confirmed because only 3 % evaluation exceeded the maximum allowed deviations. Verification images enable us to disclose wrong irradiation position, therefore only the target volume is irradiated and follows no irradiation of the surrounding healthy tissue and critical organs.
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Nursing of children on a transplant unit
HERKUCZOVÁ, Lenka
Oncological disease is very stressful and worrying for everyone. In the second half of 20th century, tumor disease became the second most frequent cause of death of children and young adults. They bring a major intervention to the child´s life, to the life of his or her family and to the lives of people close to the child. The research was proceeded on transplant unit and standard unit in Children´s Cancer Hospital. The objective of the thesis was to find out the specifics of the care on the transplant unit and based on obtained results determine actions that could make the care for children in the transplant unit more pleasant and improve the quality of the care. The objectives were fulfiled. Based on the research four hypothesis were formed.
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Awareness of patients about diagnostics and therapy of malignant gynecologic tumours
PLOJHAROVÁ, Anna
Three goals were set for the work. The first one was to find out whether women see their gynecologists once a year for the recommended preventive examination. The second goal was to asses the level of awareness among women regarding diagnostics and therapy of malignant gynecological tumours. The third goal of the work was to find out whether women are sufficiently informed about possible prevention and protection against cancer development. In connection with these goals three hypotheses were set to validate them. The first hypothesis supposed that women do not undergo yearly preventive examinations. It has not been validated by the research. The second hypothesis, that women are sufficiently informed about gynecological diseases, has proved to be correct. The third hypothesis, that women are sufficiently informed about prevention against cancer development, has also turned out to be correct.
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Comparison dose distribution of conventional radiotherapy with the application of IMRT
FÁBERA, Michal
The bachelor thesis deals with examination of techniques used in radiotherapy, and comparison of dose distribution in PTV and critical organs for conventional radiotherapy and the intensity modulated radio therapy (IMRT).The main aim of the work was to summarize present therapeutic methods in radiotherapy and to compare dose distribution in conventional radiotherapy and application of the intensity modulated radio therapy.
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