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Study of excipients' influence on the drug dissolution from tablets
Ouzký, Miroslav ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Supervisor: Consultants: Assoc. Prof. PharmDr. Zdeňka Šklubalová, Ph.D. Mgr. Jana Brokešová, Mgr. Daniel Pěček Student: Miroslav Ouzký Title of Thesis: Study of excipientsʼ influence on the drug dissolution from tablets The aim of this work was to study the influence of excipients on the dissolution of the high-dose active substance from tablets. The tablets were compressed from the granules prepared by wet-granulation method. 11 batches of tablets which contained two different fillers: either lactose or microcrystalline cellulose, respectively; and extragranularly added disintegrant: either croscarmellose or crospovidone, respectively, in three concentration levels of 2 %, 3,7 % or 5,4 % were prepared. Tablets were packed into aluminium/PVC blisters. The paddle dissolution test was used to determine the release of the active substance into phospate buffer pH 7,2 at the time of preparation (time 0) and at the time points 1.5, 3 and 6 months of stability assay at 40 řC and 75 % relative air humidity. The results show that the drug release from tablets containing microcrystalline celulose was generally faster than from those containing lactose. The same was true for tablets to which croscarmellose was...
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Influence of fillers and disintegrants type on properties of tablets with high dose drug.
Tranová, Thao ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Consultant: doc. PharmDr. Jitka Mužíková, Ph.D. Student: Thao Tranová Title of Thesis: Influence of fillers' and disintegrants' type on properties of tablets with high dose drug The work engages in the study of fillers' and extragranular superdisintegrants' influence on properties of tablets with high dose drug. Two types of granulate with lactose or microcrystalline cellulose were produced in high shear granulator. Eleven tablets groups with different type and amount of superdisintegrants were prepared from the granulates. Tablets contained 2 %, 3.7 %, 5.4 % of sodium croscarmellose or 2 % and 5.4 % of crospovidone. The tested parameters of tablets were friability, hardness, disintegration time and density. Accelerated stability studies lasting 6 months at temperature of 40 řC and relative humidity 75 % were done. The tablets were evaluated after 1.5, 3 and 6 months. All tablets had adequate friability, hardness, disintegration and density at T0. Increasing concentration of superdisintegrant decreased disintegration time. Tablets containing microcrystalline cellulose and sodium croscarmellose disintegrated faster than tablets containing lactose or crospovidone. Tablets with sodium croscarmellose had...
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The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets.
Rumlerová, Lenka ; Ondrejček, Pavel (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Consultant: PharmDr. Pavel Ondrejček, Ph.D Student: Lenka Rumlerová Title of Thesis: The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets. This thesis deals with influence of rice extract, as a new kind of glidant on compressibility of microcrystalline celulose as a model filler. Furthermore it evaluates the impact of rice extract on tablet properties. Effects of rice extract were compared with two standard glidants - magnesium stearate and colloidal silicon dioxide. As first the influence of diferent glidants concetrations on flow properties of mixtures were assesed. Tablets were compresed using three different compression forces. A force- displacement record was used to evaluate the compressibility of microcrystalline cellulose and its mixtures with glidants. Subsequently, the properties of tablets were evaluated. The radial strenght, abrasion, and tablet disintegration time were measured. The results revealed that the rice extract has the least effect on mixtures flow poperties. However, all mixtures showed a statistically significant improvement in flowability. When using a 1 % rice extract, the flow properties of the...
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The effect of particle size on lactose compressibility
Havlíková, Natálie ; Ondrejček, Pavel (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Consultant: PharmDr. Pavel Ondrejček, Ph.D. Student: Natálie Havlíková Title of Thesis: The effect of particle size on lactose compressibility It is known that the particle size of the compressed material plays an important role in the manufacture of tablets. It affects the properties of intermediate and final products. In this thesis the properties of tablets made of two lactose types, which were used as model fillers, were studied. These were Tablettose® 80 and Lactopress® Anhydrous. In both lactose types, five sieved size fractions of the particle size ranging from 9 to 346µm and their original unsieved mixture were used. The compaction forces ranging from 2 to 10kN were used for tablet preparation. Magnesium stearate was used for external lubrication. The evaluation of the prepared tablets was done mainly by using the pharmacopoeial methods. The evaluated parameters were friability, disintegration time and hardness. Furthermore, the elasticity of the tablets and the evaluation using the force-displacement method parameters were assessed. From the results of this work, it is not possible to unambiguously determine the advantage of one particular fraction size in the comparison to the...
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The effect of particle size on lactose compressibility
Havlíková, Natálie ; Ondrejček, Pavel (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Consultant: PharmDr. Pavel Ondrejček, Ph.D. Student: Natálie Havlíková Title of Thesis: The effect of particle size on lactose compressibility It is known that the particle size of the compressed material plays an important role in the manufacture of tablets. It affects the properties of intermediate and final products. In this thesis the properties of tablets made of two lactose types, which were used as model fillers, were studied. These were Tablettose® 80 and Lactopress® Anhydrous. In both lactose types, five sieved size fractions of the particle size ranging from 9 to 346µm and their original unsieved mixture were used. The compaction forces ranging from 2 to 10kN were used for tablet preparation. Magnesium stearate was used for external lubrication. The evaluation of the prepared tablets was done mainly by using the pharmacopoeial methods. The evaluated parameters were friability, disintegration time and hardness. Furthermore, the elasticity of the tablets and the evaluation using the force-displacement method parameters were assessed. From the results of this work, it is not possible to unambiguously determine the advantage of one particular fraction size in the comparison to the...
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The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets.
Rumlerová, Lenka ; Ondrejček, Pavel (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Consultant: PharmDr. Pavel Ondrejček, Ph.D Student: Lenka Rumlerová Title of Thesis: The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets. This thesis deals with influence of rice extract, as a new kind of glidant on compressibility of microcrystalline celulose as a model filler. Furthermore it evaluates the impact of rice extract on tablet properties. Effects of rice extract were compared with two standard glidants - magnesium stearate and colloidal silicon dioxide. As first the influence of diferent glidants concetrations on flow properties of mixtures were assesed. Tablets were compresed using three different compression forces. A force- displacement record was used to evaluate the compressibility of microcrystalline cellulose and its mixtures with glidants. Subsequently, the properties of tablets were evaluated. The radial strenght, abrasion, and tablet disintegration time were measured. The results revealed that the rice extract has the least effect on mixtures flow poperties. However, all mixtures showed a statistically significant improvement in flowability. When using a 1 % rice extract, the flow properties of the...
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The Use of the Touchscreen Technologies in German Language Teaching
BERKOVCOVÁ, Martina
This thesis deals with the use of mobile touch technologies in German language teaching. The theoretical part of the work collects basic facts and knowledge about mobile touch devices, which are important as a didactic tool. Furthermore, the work on the theoretical level deals with information on teaching applications and teaching methods in which these touch technologies can be used. The Practical part of the work is devoted to the results of the research survey, namely the questionnaire research survey and the results from a sample lesson. The questionnaire survey revealed that mobile touch technologies are not widely distributed in schools and are not widely used during lessons. This thesis seeks to give readers a comprehensive description of the possibilities of didactic and methodical use of mobile touch devices in the teaching of German language.
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Benefits and Difficulties of Using Multimedia Applications in French Language Teaching
CÍZLOVÁ, Kateřina
The following diploma thesis focuses on the question concerning the implementation and possibilities of using mobile touch-screen devices within the process of French language teaching. The theoretical part presents different aspects of this subject with focus on didactical, technological and especially methodical sides. The practical part describes the results of questionnaire survey in which the methods of including mobile technologies in French lessons on Czech schools and the attitudes of teachers toward these didactic tools were studied. The practical part also includes a list of multimedia applications suitable for French language classes and a set of practical activities whose aim is to show possible usage of free basic mobile application types.
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The influence of modern technologies on teaching geography
Firlová, Veronika ; Hanus, Martin (advisor) ; Fikarová, Veronika (referee)
This diploma thesis aims to ascertain on the basis of the qualitative research how are tablet computers used in geography lessons, what positive and negative aspects are found and if using of the tablet computers can influence a conception of geography lessons. The main aim is achieved by doing qualitative interviews with lower secondary teachers of geography. To achieve the main aim it as initially necessary to achieve artial aims. Firstly, the term modern technology was defined. Afterwards, the specific technology which will be examined in this diploma thesis in relation to a change the way of teaching was described. The description of pros and cons of utilization of tablet computers in classes was used in the creation of the scenario for the interview. Each teacher can influence teaching with his own approach as well as his attitude, which is involved in the preparation of lessons and the choice of using tablet computers. Essential partial aim is to describe the qualitative research after which the questionnaire could be created and interviews performed and evaluated. Based on the results it could be stated that teachers use the tablet computers in two ways The first way is the usage of computer application to revise the subject matter. This way of using the tablet computers does not influence...
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Dissolution testing of tablets containing theophylline and mixtures of two types of calcium hydrogen phosphates and microcrystalline cellulose
Vávrová, Kateřina ; Ondrejček, Pavel (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical technology Consultant: PharmDr. Pavel Ondrejček, Ph.D. Student: Kateřina Vávrová Title of Thesis: Dissolution testing of tablets containing theophylline and mixtures of two types of calcium hydrogen phosphates and microcrystalline cellulose The aim of this thesis was the dissolution testing of tablets containing theophylline, the mixture of two dicalcium phosphate types and microcrystalline cellulose. The influence of tablet composition on the dissolution profiles was evaluated. The tablets were prepared from the mixtures containing microcrystalline cellulose, dicalcium phosphate anhydrous and dihydrate. These substances were used as fillers. Prepared mixtures contained theophylline as a model active ingredient and magnesium stearate as lubricant. Afterwards, the dissolution tests were done. For these tests, the basket method was utilized. As a dissolution medium the 0,1M hydrochloric acid solution was used. From the results of this experiment we concluded that we can influence the total amount of released theophylline and the speed of its release by the different ratio of microcrystalline cellulose and one of dicalcium phosphate types. The fastest theophylline dissolution was in tablets with high...
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