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Clinical aspects of the squamous cell carcinoma of the oral cavity and lip
Nováková, Vendula ; Slezák, Radovan (advisor) ; Pazdera, Jindřich (referee) ; Broukal, Zdeněk (referee)
Clinical aspects of the squamous cell carcinoma of the oral cavity and lip Introduction: The incidence of head and neck cancer in Czech Republic is rising. Despite the recent advances in treatment, no significant drop in fatality of the disease has been noted in the last decades. The aim of the study was to describe relevant clinical and demographic characteristics and their impact on survival of a case series with oral squamous cell carcinoma (OSCC). Material and methods: Two-hundred patients with OSCC diagnosed and treated at the Department of Dentistry, Charles University in Prague, Faculty of Medicine and Teaching Hospital in Hradec Králové, were included in this retrospective descriptive study. Information about sex, age, risk factors, site of the tumour, histologic findings, stage of disease, primary treatment method and cause of death were analyzed. The Kaplan-Meier method and Cox regression were used for survival analysis. Results: The median of follow up was 28 months (range 1-242 months). The male to female ratio was 2.1:1. The mean age of the patients was 62 years (SD=12). The most common areas affected by carcinoma were floor of mouth (51 cases, 25,5%) and lower lip (47 cases, 23,5%). One-hundred-and-four patients ...
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