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Studying of atorvastatin effects on atherogenesis in apoE-/-/LDLR-/- double knock-out mouse model of atherosclerosis II.
 Zajíčková, Jana ; Nachtigal, Petr (advisor) ; Štaud, František (referee)
Atherosclerosis is a degenerative disease of blood-vessel wall, which attacks all population. It is very widespreaded and nowadays it is also one of the most frequent causes of death in the all economically advanced countries. In recent years the extensive research of atherosclerosis have brought a number of new pieces of knowledges, which have contributed to understanding of actions that happen during the process of atherogenesis. ApoE/LDL - receptor double knockout mice represent an animal model for study of atherogenesis, which is able to evolve severe hyperlipidaemia and atherosclerosis. Statins are currently the most considerable and the most useful hypolipidemic drugs. They significantly decrease levels of total cholesterol and LDL cholesterol and also decrease mortality and morbidity of cardiovascular diseases. The aim of the diploma thesis was to find out and describe the expression of SMAD 2/3 in atherosclerotic plaques in apoE/LDL-receptor deficient mice and to study possible atorvastatin effects on its expression. The female mice at the age of eight weeks were used in the study. Animals were divided �into� two �groups. The �control� group �of �animals� was fed with the western type diet.����same atherogenic diet was�used in��atorvastatin group,�where�atorvastatin�was�added to the...
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