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Investigation of the effect of creatine in combination with magnesium and vitamin C on the performance of the individual person
Vlasák, Jan ; Němcová, Andrea (referee) ; Diviš, Pavel (advisor)
Creatine is nitrogen-containing organic acid which naturally occurs in the human body. The aim of this work was to determine the optimal dose of creatine in combination with vitamin C and magnesium for male respondents aged 18-26 years. They were divided into two groups differing in the creatine dosage. Group 1 took smaller dose of creatine (3 g per day) and group 2 higher dose of creatine (10 g per day). Both groups took both magnesium and vitamin C at constant doses throughout the study. The effects of significantly different dose of creatine in the individual groups were compared with each other in terms of the performance of individuals in the powerlifting, the anthropological changes and the overal metabolism of the intakes. In all disciplines of powerlifting, group 1 recorded higher average weight gains, which were not found to be statistically significant at a significance level of alpha 0,05. Anthropological changes were measured using the InBody 160 and a diagnostic measuring tape. In both cases, group 1 recorded better results than group 2, but these results were not statistically significant at a significance level of alpha 0,05. The total metabolism of the accepted dietary supplements was investigated through analytical methods. The urine of each respondent was regularly collected and subsequently analyzed during the research. Determination of creatinine, a creatine waste product, was performed by UV-VIS spectrophotometry using the Jaffe reaction. Vitamin C was analyzed by RP-HPLC. Magnesium was determined by the ICP-OES method. After creatine suplemantion of 3 per day, group 1 showed a slight increase in creatinine in the urine, but still in the physiological range. At the significance level alpha 0,05 there was no statistically significant difference. Group 2 showed an increase above the physiological limit which was already a statistically significant difference. Overall, creatine supplementation of 3 g per day has been found as a sufficient intake of creatine needed to build up muscle mass, increase energy metabolism and overall physical performance. The metabolization itself works very well and within the physiological values.
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Dietary supplements in sport nutrition and possibilities of monitoring their effect on efficiency of sportsman.
Vlčková, Lenka ; Hrstka, Miroslav (referee) ; Vránová, Dana (advisor)
This work deals with dietary supplements intake and its impact on the performance rise and muscle mass growth of bodybuilders. Twenty-five students (bodybuilders) were chosen for the purpose of this survey; they were divided into four groups according to the dosage of creatine and other dietary supplements (proteins and maltodextrine). Changes of the measured parameters (weight; bustline; weistline; limb girth; body lipid content; creatine and urea content in the urine) were compared during the survey. The tested dietary supplements impact on the muscle mass growth was evaluated on the basis of the acquired results.
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Preparation of patient prior to application intravenous of contrast medium in relation to the prevention of renal failure
PUCHOLTOVÁ, Lenka
The topic of the bachelor thesis is the patient preparation prior to intravenous contrast in relation to the prevention of renal failure. The theoretical part deals with the anatomy and physiology of the kidney, provides information about the contrast media of their properties, uses and side effects. At the end of the theoretical part describes the contrast medium-induced nephropathy. In the practical part I focused on finding out what is the incidence of contrast nephropathy in individuals with normal creatinine levels depending on the amount of contrast agent and the preparation of the patient. I obtained the data from the hospital information system Masaryk Hospital Townsville. The database contained a set of hospitalized patients in the years 2009 - 2011, which were performed CT examinations associated with the administration of iodinated contrast media. Part of the personal data of patients, the tests used, the type and amount of contrast agent and creatinine values. Since creatinine values were available for all patients, the final database was created from 938 patients with baseline of normal creatinine levels before the examination for which they may be level <than 130 mmol/l. The final group of patients was analyzed according to the defined aims and statistically processed. Hypothesis of this study: the incidence of contrast nephropathy in individuals with normal creatinine levels depending on the amount of contrast agent as a suitable preparation of patients prior to administration of iodinated contrast material does not exceed 10% - was confirmed. In the investigated group of patients was proved preventive effect of patient preparation before the test - hydration. A higher incidence of CN was observed in the group of patients whose preparation has taken place.
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