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Syntéza a vlastnosti chirálních acyklických nukleosid bisfosfonátů s otevřeným kruhem
Doláková, Petra ; Masojídková, Milena ; Holý, Antonín
A new type of acyclic nucleoside phosphonates (ANP) is derived from 2,4-diamino-6-hydroxypyrimidine. These 6-[2-(phosphonomethoxy)ethoxy]pyrimidine derivatives significantly inhibit replication of retroviruses and herpesviruses in cell cultures. This novel subclass of pyrimidine ANPs can be considered as analogues of 2,6-diaminopurine with an open imidazole ring in the purine moiety.

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