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Late effects of oncolocigal treatment for childhood cancers
Zichová, Andrea ; Eckschlager, Tomáš (advisor) ; Kolenová, Alexandra (referee) ; Tesařová, Petra (referee)
Late effects of oncological treatment for childhood cancers Abstract The study aimed to describe the occurence of subsequent neoplasms and their risk factors at the Departement of Pediatric Haematology and Oncology, Motol University Hospital, Prague. Moreover, we focused on sporadic renal angiomyolipomas as the most frequent benign subsequent neoplasms. Out of 4,059 survivors treated between 1975 - 2018 for a solid tumor on Departement of Pediatric Haematology and Oncology, 170 (4.2 % of all survivors) had at least one subsequent malingant neoplasm, 21 of them (0.5 of all survivors) developed more subsequent malignant neoplasms, and 34 (0.8 of all survivors) developed one subsequent malignant neoplasm and at least one subsequent benign neoplasm. Mortality among patients with subsequent malignant neoplasm was 38 %, i.e. 1.6 % of all survivors. The most common subsequent malignant neoplasms was thyroid carcinoma (37; 19.2 %), central nervous system tumors (25; 13 %), and soft tissue sarcomas (23; 11.9 %). 119 (2.9 %) survivors developed only subsequent benign neoplasm. Out of 1,098 survivors who underwent ultrasound examination between 2014 - 2019, 48 (4.4 %) had sporadic renal angiomyolipoma; moreover, 20 of them also had another subsequent neoplasm. The median age at diagnosis was 27.9 years, and the median...
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Use of Model Administrative Activities in Prevocational Assessment
Zichová, Andrea ; Rybářová, Kateřina (advisor) ; Uhlířová, Jaromíra (referee)
This bachelor thesis deals with model activities, which are focused on administrative activities due to possible employment of people with disability. Occupational therapists perform model activities within prevocational assessment or occupational therapy to determine whether a test person has the abilities, knowledge and skills needed to perform a given type of job. The aim of this bachelor thesis is to compile a set of administrative model activities usable in occupational therapy for people with disability in productive age. It also describes the work of an administrative worker, including his working environment. A separate chapter summarizes the basic facts about prevocational assessment. Model activities that are an integral part of prevocational assessment are presented in more detail. The practical part describes how six administrative model activities were created, which were pilot tested on healthy individuals. The created model activities were subsequently applied to persons with disability within occupational therapy and also during prevocational assessment examination to verify their applicability in practice. Results from this application are presented in the form of six case reports. Manuals on all created model activities are included in the annexes of the bachelor thesis....
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