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Návrh a syntéza inhibitorů DDl založených na isothiazolidinonovém jádře
Suchanová, Klára ; Zimčík, Petr (advisor) ; Miletín, Miroslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug control Candidate: Klára Suchanová Supervisor: doc. dr. Marko Anderluh, mag. farm.; PharmDr. Petr Zimčík, Ph.D. Title of diploma thesis: Design and synthesis of isothiazolidinone-based DDl inhibitors This work is focused on D-Ala-D-Ala ligase (DDl), enzyme in alanine side pathway of the bacterial cell wall synthesis. Potential DDl inhibitors were designed with the help of docking software (AutoDock 4.05, The Scripps Research Institute, La Jolla, USA), X-ray structures of DDl (1IOW and 1IOV, PDB), its natural substrates/products and known published inhibitors. This work is a part of the project EUR-INTAFAR (Inhibition of New TArgets for Fighting Antibiotic Resistance) aiming at better understanding of the physiology and biochemistry of bacterial cell morphogenesis and peptidoglycan biosynthesis and the discovery of new antibacterial agents. According to the in silico design, five final compounds were synthesized with isothiazolidinone core and evaluated in the biological assays to determine their DDl inhibitory potency.
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The comparative kineziologic analysis of forward stroke on wheelchair and crawling
Vatěrová, Hana ; Kračmar, Bronislav (advisor) ; Suchanová, Klára (referee)
Title: The comparative kineziologic analysis of forward stroke on wheelchair and crawling. Objectives of the Thesis: The aim of the thesis is to compare muscle activity of selected muscles in shoulder girdle during forward stroke on wheelchair and crawling. Method: Surface electromyography combinated with kinematography analysis used synchronized video recording. Results and Conclusions: As the research shows, there is a difference in muscle activity (timing) between forward stroke on wheelchair and during crawling. It was proved that the activity of forward stroke on wheelchair does not have natural locomotive character. Keywords: Forward stroke on wheelchair, crawling, shoulder girdle, surface electromyography, kinematics analysis.
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The comparative kineziologic analysis of forward stroke on wheelchair and crawling
Vatěrová, Hana ; Kračmar, Bronislav (advisor) ; Suchanová, Klára (referee)
Title: The comparative kineziologic analysis of forward stroke on wheelchair and crawling. Objectives of the Thesis: The aim of the thesis is to compare muscle activity of selected muscles in shoulder girdle during forward stroke on wheelchair and crawling. Method: Surface electromyography combinated with kinematography analysis used synchronized video recording. Results and Conclusions: As the research shows, there is a difference in muscle activity (timing) between forward stroke on wheelchair and during crawling. It was proved that the activity of forward stroke on wheelchair does not have natural locomotive character. Keywords: Forward stroke on wheelchair, crawling, shoulder girdle, surface electromyography, kinematics analysis.
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Návrh a syntéza inhibitorů DDl založených na isothiazolidinonovém jádře
Suchanová, Klára ; Miletín, Miroslav (referee) ; Zimčík, Petr (advisor)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug control Candidate: Klára Suchanová Supervisor: doc. dr. Marko Anderluh, mag. farm.; PharmDr. Petr Zimčík, Ph.D. Title of diploma thesis: Design and synthesis of isothiazolidinone-based DDl inhibitors This work is focused on D-Ala-D-Ala ligase (DDl), enzyme in alanine side pathway of the bacterial cell wall synthesis. Potential DDl inhibitors were designed with the help of docking software (AutoDock 4.05, The Scripps Research Institute, La Jolla, USA), X-ray structures of DDl (1IOW and 1IOV, PDB), its natural substrates/products and known published inhibitors. This work is a part of the project EUR-INTAFAR (Inhibition of New TArgets for Fighting Antibiotic Resistance) aiming at better understanding of the physiology and biochemistry of bacterial cell morphogenesis and peptidoglycan biosynthesis and the discovery of new antibacterial agents. According to the in silico design, five final compounds were synthesized with isothiazolidinone core and evaluated in the biological assays to determine their DDl inhibitory potency.
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Introduction to Freestyle Snowboarding
Suchanová, Klára ; Vomáčko, Ladislav (advisor) ; Matošková, Petra (referee)
Název práce: Úvod do freestyle snowboardingu Introduction to ťreestyle snowboarding Cíle práce: Sestavení metodické řady pro výuku ťreestyle snowboardingu. Výklad širších souvislostí freestyle snowboardingu. Metoda: Metodická řada freestyle snowboardingu byla vytvořena na základě analýzy textů a dokumentů a empirického pozorování v dané oblasti. Výsledky: Metodická řada freestyle snowboardingu. Pojednání o záležitostech freestyle snowboardingu. Klíčová slova: freestyle snowboarding, metodická řada, rozhodování ve snowboardingu, snowboardové organizace, teorie triků.
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