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Biological age prediction using DNA analysis
Stokičová, Linda ; Vaněk, Daniel (advisor) ; Tomášek, Petr (referee)
Eye colour, hair colour and biogeographical origin can be predicted based on DNA analysis. This is used in forensic genetics when an unknown perpetrator leaves a biological material on a crime scene. Prediction of biological age is the subject of further research. Nowadays, there is no standardised model, which can be used for accurate prediction. The best option for biological age prediction is DNA methylation - stable epigenetic modification. Many markers have been evaluated. Methylation of these markers correlates with biological age positively or negatively. Methylation has tissue specificity, so one model cannot be applied on all types of tissues. Model for biological age prediction can be applied during investiganting of a criminal activity, when the identity of a person commiting a crime is unknown. Key words: methylation, chronological age, biological age, DNA analysis, forensic genetics
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