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Gene Searching - Web Application
Stiborová, Lucie ; Koutný, Jiří (referee) ; Burgetová, Ivana (advisor)
The aim of my Bachelor's Thesis is to create a user interface and to implement the web application with the genes' searching. This is the educational application when each user has a possibility of entering own nucleotide sequences or selecting a redefined chain. This application has to be able to read, process and decide on the existence of a potential gene. On the base of this simple statistic method the result is given back to the user.
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Modeling of the Influence of Genetics in Insurance
Stiborová, Lucie ; Bohumský, Petr (advisor) ; Jarolímková, Tereza (referee)
This diploma thesis is denoted to application of continuous time multiple state Markov models in respect to the Alzheimer's disease in critical illness insurance, long-term care insurance and life insurance. It solves the impact of insurer's access to applicant's genetic information, the possibility of misusage of this information and the questions of fairness in insurance. It defines some mathematical methods, basic definitions of genetics, it describes the Alzheimer's disease and its forms. It shows model's using during determining cost of adverse selection and the impact of Alzheimer's disease in long-term care insurance. On the basis of model there are estimated the transition intensities among states. We use this intensities to estimate the mortality of lives with Alzheimer's disease and the cost in long-term care insurance. The models show dividing the population into more risk groups and it is possible to model the risk of adverse selection caused by asymmetric information about genetic test result.
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Modeling of the Influence of Genetics in Insurance
Stiborová, Lucie ; Bohumský, Petr (advisor) ; Jarolímková, Tereza (referee)
This diploma thesis is denoted to application of continuous time multiple state Markov models in respect to the Alzheimer's disease in critical illness insurance, long-term care insurance and life insurance. It solves the impact of insurer's access to applicant's genetic information, the possibility of misusage of this information and the questions of fairness in insurance. It defines some mathematical methods, basic definitions of genetics, it describes the Alzheimer's disease and its forms. It shows model's using during determining cost of adverse selection and the impact of Alzheimer's disease in long-term care insurance. On the basis of model there are estimated the transition intensities among states. We use this intensities to estimate the mortality of lives with Alzheimer's disease and the cost in long-term care insurance. The models show dividing the population into more risk groups and it is possible to model the risk of adverse selection caused by asymmetric information about genetic test result.
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|
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Gene Searching - Web Application
Stiborová, Lucie ; Koutný, Jiří (referee) ; Burgetová, Ivana (advisor)
The aim of my Bachelor's Thesis is to create a user interface and to implement the web application with the genes' searching. This is the educational application when each user has a possibility of entering own nucleotide sequences or selecting a redefined chain. This application has to be able to read, process and decide on the existence of a potential gene. On the base of this simple statistic method the result is given back to the user.
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